Detailed information of TA system TA058116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2110528..2111152
• Replicon: chromosome
• Accession: NZ_CP013202
• Organism: Streptococcus agalactiae strain GBS ST-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: AOY37_RS10630
• Protein ID: WP_000253103.1
• Coordinates: 2110528..2110875 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: AOY37_RS10635
• Protein ID: WP_000543070.1
• Coordinates: 2110865..2111152 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY37_RS10610	2106243..2106599	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
AOY37_RS10615	2106666..2108984	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
AOY37_RS10620	2109123..2109662	+	540	WP_029140677.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
AOY37_RS10625	2109748..2110044	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
AOY37_RS10630	2110528..2110875	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AOY37_RS10635	2110865..2111152	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AOY37_RS10640	2111221..2111598	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
AOY37_RS11685	2111573..2111725	-	153	Protein_2038	DUF1492 domain-containing protein	-
AOY37_RS10645	2111732..2112220	-	489	WP_000891151.1	hypothetical protein	-
AOY37_RS10650	2112293..2112850	-	558	WP_001258765.1	hypothetical protein	-
AOY37_RS11520	2113008..2113181	-	174	WP_000694573.1	hypothetical protein	-
AOY37_RS10655	2113178..2113435	-	258	WP_001069293.1	hypothetical protein	-
AOY37_RS10660	2113728..2115122	-	1395	WP_000656430.1	hypothetical protein	-
AOY37_RS10665	2115134..2115991	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2105366..2124326	18960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T58116 WP_000253103.1 NZ_CP013202:c2110875-2110528 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T58116 NZ_CP013202:c2110875-2110528 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTATCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT58116 WP_000543070.1 NZ_CP013202:c2111152-2110865 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT58116 NZ_CP013202:c2111152-2110865 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5