Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 249400..250012 Replicon chromosome
Accession NZ_CP013202
Organism Streptococcus agalactiae strain GBS ST-1

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag AOY37_RS01435 Protein ID WP_000384858.1
Coordinates 249400..249735 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag AOY37_RS01440 Protein ID WP_000255538.1
Coordinates 249725..250012 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY37_RS01410 244575..245204 + 630 WP_000591148.1 hypothetical protein -
AOY37_RS01415 245540..246415 + 876 WP_000770113.1 hypothetical protein -
AOY37_RS01420 246451..246885 + 435 WP_001220479.1 hypothetical protein -
AOY37_RS01425 247201..248457 + 1257 WP_000122832.1 plasmid recombination protein -
AOY37_RS01430 248625..249095 + 471 WP_000130119.1 hypothetical protein -
AOY37_RS01435 249400..249735 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOY37_RS01440 249725..250012 - 288 WP_000255538.1 hypothetical protein Antitoxin
AOY37_RS01445 250415..251635 - 1221 WP_000156558.1 tyrosine-type recombinase/integrase -
AOY37_RS01450 251696..251956 - 261 WP_001196072.1 helix-turn-helix domain-containing protein -
AOY37_RS01455 251968..252714 - 747 WP_000966632.1 hypothetical protein -
AOY37_RS01460 252900..253691 - 792 WP_001868842.1 hypothetical protein -
AOY37_RS01465 253672..254205 - 534 WP_000680721.1 hypothetical protein -
AOY37_RS01470 254205..254543 - 339 WP_001187920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 231468..250276 18808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T58114 WP_000384858.1 NZ_CP013202:c249735-249400 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T58114 NZ_CP013202:c249735-249400 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT58114 WP_000255538.1 NZ_CP013202:c250012-249725 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT58114 NZ_CP013202:c250012-249725 [Streptococcus agalactiae]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References