Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3529976..3530594 Replicon chromosome
Accession NZ_CP013190
Organism Escherichia coli strain FORC_031

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FORC31_RS17590 Protein ID WP_001291435.1
Coordinates 3530376..3530594 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag FORC31_RS17585 Protein ID WP_000344789.1
Coordinates 3529976..3530350 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC31_RS17575 3525065..3526258 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FORC31_RS17580 3526281..3529430 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
FORC31_RS17585 3529976..3530350 + 375 WP_000344789.1 Hha toxicity modulator TomB Antitoxin
FORC31_RS17590 3530376..3530594 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FORC31_RS17595 3530766..3531317 + 552 WP_000102564.1 maltose O-acetyltransferase -
FORC31_RS17600 3531433..3531903 + 471 WP_000136192.1 YlaC family protein -
FORC31_RS17605 3532067..3533617 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FORC31_RS17610 3533659..3534012 - 354 WP_000878143.1 DUF1428 domain-containing protein -
FORC31_RS17620 3534391..3534702 + 312 WP_000409911.1 MGMT family protein -
FORC31_RS17625 3534733..3535305 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T58105 WP_001291435.1 NZ_CP013190:3530376-3530594 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T58105 NZ_CP013190:3530376-3530594 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14569.44 Da        Isoelectric Point: 4.7395

>AT58105 WP_000344789.1 NZ_CP013190:3529976-3530350 [Escherichia coli]
MDEYSPKRHDIAQLKFLCEILYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT58105 NZ_CP013190:3529976-3530350 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAATCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References