Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 240839..241428 Replicon chromosome
Accession NZ_CP013189
Organism Pseudohongiella spirulinae strain KCTC 32221

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PS2015_RS01260 Protein ID WP_058020462.1
Coordinates 240839..241093 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PS2015_RS01265 Protein ID WP_058020463.1
Coordinates 241090..241428 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS2015_RS01190 235878..236165 + 288 WP_058020450.1 HigA family addiction module antidote protein -
PS2015_RS01195 236311..236568 + 258 WP_058020451.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PS2015_RS01200 236556..236867 + 312 WP_058023079.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS2015_RS01205 237007..237321 + 315 WP_058020452.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS2015_RS01210 237308..237586 + 279 WP_058020453.1 putative addiction module antidote protein -
PS2015_RS01215 237735..237998 + 264 WP_058020454.1 BrnT family toxin -
PS2015_RS01220 237988..238257 + 270 WP_058020455.1 hypothetical protein -
PS2015_RS01225 238326..238628 + 303 WP_058020456.1 type II toxin-antitoxin system HigB family toxin -
PS2015_RS01230 238637..239017 + 381 WP_058020457.1 hypothetical protein -
PS2015_RS01235 239141..239383 + 243 WP_058023080.1 hypothetical protein -
PS2015_RS01240 239428..239706 + 279 WP_058020458.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS2015_RS01245 239706..239999 + 294 WP_058020459.1 HigA family addiction module antidote protein -
PS2015_RS01250 240073..240465 - 393 WP_058020460.1 PIN domain nuclease -
PS2015_RS01255 240462..240656 - 195 WP_058020461.1 type II toxin-antitoxin system VapB family antitoxin -
PS2015_RS01260 240839..241093 + 255 WP_058020462.1 type II toxin-antitoxin system HicA family toxin Toxin
PS2015_RS01265 241090..241428 + 339 WP_058020463.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PS2015_RS01270 241505..241777 - 273 WP_058020464.1 BrnA antitoxin family protein -
PS2015_RS01275 241764..242063 - 300 WP_058020465.1 BrnT family toxin -
PS2015_RS01280 242255..242461 + 207 WP_058020466.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
PS2015_RS01285 242458..242838 + 381 WP_058020467.1 type II toxin-antitoxin system VapC family toxin -
PS2015_RS01290 242905..243234 - 330 WP_058020468.1 helix-turn-helix domain-containing protein -
PS2015_RS15380 243221..243559 - 339 WP_082627888.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS2015_RS01295 243710..244159 + 450 WP_058020469.1 hypothetical protein -
PS2015_RS01300 244291..244635 + 345 WP_058020470.1 hypothetical protein -
PS2015_RS01305 244717..245034 - 318 WP_058020471.1 CcdB family protein -
PS2015_RS01310 245034..245279 - 246 WP_058020472.1 type II toxin-antitoxin system CcdA family antitoxin -
PS2015_RS15385 245525..245926 + 402 WP_082627889.1 GFA family protein -
PS2015_RS15560 245999..246100 + 102 Protein_263 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9658.12 Da        Isoelectric Point: 10.8980

>T58086 WP_058020462.1 NZ_CP013189:240839-241093 [Pseudohongiella spirulinae]
MKRKHQKTLESIFARPVSANIQWRDIEALFVELGAEITEREGSRVAVVLFGEVRVFHRPHPSPNTDKGAVASIRKWLEQH
RVSL

Download         Length: 255 bp

>T58086 NZ_CP013189:240839-241093 [Pseudohongiella spirulinae]
ATGAAGCGTAAGCACCAAAAAACCCTGGAATCAATCTTTGCCCGTCCGGTAAGCGCTAATATCCAATGGCGTGACATCGA
GGCATTGTTCGTCGAGCTTGGAGCGGAGATTACGGAGCGCGAAGGTAGCCGGGTTGCCGTGGTGCTTTTCGGTGAGGTTC
GAGTTTTTCATCGCCCTCATCCAAGTCCAAATACTGACAAAGGTGCTGTAGCCAGTATTCGCAAGTGGCTAGAGCAGCAT
AGGGTATCACTATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12722.46 Da        Isoelectric Point: 7.3561

>AT58086 WP_058020463.1 NZ_CP013189:241090-241428 [Pseudohongiella spirulinae]
MNTMTYDGYHAKIEYDAELDTFRGEILGLNGGADFYGRNPKELRAEFKKSLHVFLEVCKEKGIEPRRHYSGKFNLRIPPE
LHEQLAIAAQVKGTSVNKLAQEALQKEIRDAG

Download         Length: 339 bp

>AT58086 NZ_CP013189:241090-241428 [Pseudohongiella spirulinae]
ATGAATACAATGACATATGATGGTTATCACGCCAAAATTGAGTATGACGCAGAGTTGGATACATTTAGAGGTGAAATTCT
AGGGTTGAATGGAGGCGCAGATTTTTATGGCCGCAACCCGAAGGAGCTGCGAGCAGAATTTAAGAAGTCGTTACACGTCT
TTCTTGAGGTATGCAAAGAGAAAGGTATCGAGCCTCGCCGCCATTATTCAGGTAAATTTAATCTCCGAATCCCGCCTGAG
CTGCATGAACAATTGGCCATTGCGGCGCAAGTAAAAGGTACAAGCGTCAATAAACTCGCGCAAGAGGCACTTCAGAAAGA
GATACGAGATGCCGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References