Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3101974..3102772 Replicon chromosome
Accession NZ_CP013185
Organism Escherichia coli strain FORC_029

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3L4GA68
Locus tag FORC29_RS16450 Protein ID WP_000854898.1
Coordinates 3101974..3102351 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L4GA79
Locus tag FORC29_RS16455 Protein ID WP_001390639.1
Coordinates 3102398..3102772 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC29_RS16415 3097562..3098116 - 555 WP_001001902.1 molecular chaperone YcdY -
FORC29_RS16420 3098140..3098877 - 738 WP_000283664.1 zinc-binding phosphatase -
FORC29_RS16425 3098932..3099870 - 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
FORC29_RS16435 3100341..3101183 - 843 WP_000014507.1 DUF4942 domain-containing protein -
FORC29_RS16440 3101280..3101477 - 198 WP_000839285.1 DUF957 domain-containing protein -
FORC29_RS16445 3101489..3101977 - 489 WP_000761668.1 hypothetical protein -
FORC29_RS16450 3101974..3102351 - 378 WP_000854898.1 TA system toxin CbtA family protein Toxin
FORC29_RS16455 3102398..3102772 - 375 WP_001390639.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FORC29_RS16460 3102852..3103073 - 222 WP_000692352.1 DUF987 domain-containing protein -
FORC29_RS16465 3103160..3103636 - 477 WP_001186776.1 RadC family protein -
FORC29_RS16470 3103652..3104137 - 486 WP_000213691.1 antirestriction protein -
FORC29_RS16475 3104229..3105047 - 819 WP_001234635.1 DUF945 domain-containing protein -
FORC29_RS27945 3105141..3105319 + 179 Protein_3011 hypothetical protein -
FORC29_RS16485 3105458..3105871 - 414 WP_000789536.1 hypothetical protein -
FORC29_RS16490 3106141..3106680 - 540 WP_001104026.1 DUF4339 domain-containing protein -
FORC29_RS16495 3106806..3107264 - 459 WP_000771527.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.07 Da        Isoelectric Point: 8.5190

>T58065 WP_000854898.1 NZ_CP013185:c3102351-3101974 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T58065 NZ_CP013185:c3102351-3101974 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13566.36 Da        Isoelectric Point: 6.0568

>AT58065 WP_001390639.1 NZ_CP013185:c3102772-3102398 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT58065 NZ_CP013185:c3102772-3102398 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGACATCAGCATACCGCCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4GA68

Antitoxin

Source ID Structure
AlphaFold DB A0A3L4GA79

References