58049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/-
Location 6916709..6917316 Replicon chromosome
Accession NZ_CP013184
Organism Pseudomonas protegens strain H78

Toxin (Protein)


Gene name PfiT Uniprot ID A0A7U9LCE3
Locus tag H78_RS31610 Protein ID WP_025131511.1
Coordinates 6916709..6917053 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A7Y1CEW2
Locus tag H78_RS31615 Protein ID WP_025131512.1
Coordinates 6917068..6917316 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H78_RS31595 6912794..6913285 - 492 WP_011064291.1 5-(carboxyamino)imidazole ribonucleotide mutase -
H78_RS31600 6913810..6914724 - 915 WP_011064292.1 LysR family transcriptional regulator -
H78_RS31605 6914906..6916330 + 1425 WP_041120431.1 aspartate ammonia-lyase -
H78_RS31610 6916709..6917053 - 345 WP_025131511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H78_RS31615 6917068..6917316 - 249 WP_025131512.1 prevent-host-death protein Antitoxin
H78_RS31620 6917920..6918276 + 357 WP_015637507.1 DUF3077 domain-containing protein -
H78_RS31625 6918478..6919203 + 726 WP_187682862.1 hypothetical protein -
H78_RS31630 6919302..6919949 + 648 WP_015637509.1 hypothetical protein -
H78_RS31635 6919997..6921016 + 1020 WP_077934964.1 beta-ketoacyl-ACP synthase 3 -
H78_RS31640 6921016..6922023 + 1008 WP_015637511.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12896.62 Da        Isoelectric Point: 4.2986

>T58049 WP_025131511.1 NZ_CP013184:c6917053-6916709 [Pseudomonas protegens]
MPTLTIRYTETAQQSIEDQIVHLADYSDLKSAFERLEAVIDALQDKLLSAPLGYPVSPQASDLGILHYRELNTDGYRVFY
EIVDADQAIVIGLVLRDKQSVEQALIRYCLLHTD

Download         Length: 345 bp

>T58049 NZ_CP013184:c6917053-6916709 [Pseudomonas protegens]
ATGCCAACACTGACAATCCGCTACACCGAAACCGCACAGCAAAGCATTGAAGACCAGATTGTGCATCTGGCCGACTATAG
CGACCTTAAGTCTGCCTTTGAGCGGTTGGAAGCTGTGATTGACGCTCTTCAGGACAAGCTCTTGTCCGCCCCGCTAGGCT
ACCCAGTCAGCCCTCAAGCAAGCGACCTGGGCATCTTGCATTACCGTGAGCTCAACACCGATGGATACCGGGTGTTCTAC
GAAATCGTGGATGCGGATCAGGCGATCGTGATTGGGCTGGTGCTGCGGGATAAGCAAAGCGTCGAGCAGGCACTTATTCG
TTACTGTCTGCTGCATACCGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9410.89 Da        Isoelectric Point: 9.8184

>AT58049 WP_025131512.1 NZ_CP013184:c6917316-6917068 [Pseudomonas protegens]
MRVETVSFLKRYASDLPLEEPMVVTQNGVPVYVVESYVERKRRDEAVALVKLLAVSSREYAQGKHCSTDELKARLSKRFA
HK

Download         Length: 249 bp

>AT58049 NZ_CP013184:c6917316-6917068 [Pseudomonas protegens]
ATGCGAGTTGAAACGGTCAGCTTTTTAAAACGATATGCCTCCGATCTGCCGTTAGAGGAGCCAATGGTCGTTACGCAAAA
CGGTGTGCCTGTTTACGTTGTCGAGTCTTACGTTGAGCGTAAGCGCCGCGACGAGGCAGTGGCGTTGGTGAAATTGCTCG
CAGTCAGTTCGCGCGAGTACGCCCAAGGCAAGCATTGTTCGACTGATGAGCTGAAGGCCCGCTTAAGCAAGAGGTTTGCC
CACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LCE3

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y1CEW2

References