Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4277744..4278399 Replicon chromosome
Accession NZ_CP013184
Organism Pseudomonas protegens strain H78

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H78_RS19490 Protein ID WP_053159224.1
Coordinates 4277744..4277923 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H78_RS19495 Protein ID WP_053159226.1
Coordinates 4277974..4278399 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H78_RS19465 4273143..4273418 + 276 WP_011061856.1 peptidylprolyl isomerase -
H78_RS19470 4273478..4274386 - 909 WP_077934397.1 sugar kinase -
H78_RS19475 4274636..4275853 - 1218 WP_015636023.1 amino acid deaminase -
H78_RS19480 4275901..4276665 - 765 WP_011061859.1 IclR family transcriptional regulator -
H78_RS19485 4276799..4277188 - 390 WP_011061860.1 RidA family protein -
H78_RS32815 4277507..4277734 + 228 WP_187682895.1 hypothetical protein -
H78_RS19490 4277744..4277923 + 180 WP_053159224.1 type II toxin-antitoxin system HicA family toxin Toxin
H78_RS19495 4277974..4278399 + 426 WP_053159226.1 transcriptional regulator Antitoxin
H78_RS19500 4278487..4279032 - 546 WP_053159228.1 hypothetical protein -
H78_RS19505 4279218..4280651 - 1434 WP_019095389.1 RtcB family protein -
H78_RS19510 4281159..4282175 - 1017 WP_077934398.1 type 1 fimbrial protein -
H78_RS19515 4282482..4283054 + 573 WP_019095391.1 glutamine amidotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6632.67 Da        Isoelectric Point: 11.1475

>T58047 WP_053159224.1 NZ_CP013184:4277744-4277923 [Pseudomonas protegens]
MKFSEFRRWLKAQGVVFEAGKGSHFKVTAPNGNKTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T58047 NZ_CP013184:4277744-4277923 [Pseudomonas protegens]
ATGAAATTCAGCGAATTCAGACGGTGGTTGAAAGCTCAAGGCGTGGTCTTCGAGGCCGGTAAAGGCAGCCACTTCAAAGT
CACGGCCCCAAACGGCAACAAGACCACCTTCGCGGATCACGGCAGCAAGGAAATGCCCGAACCCACCCGCAAGGCAATCA
TCAGGCAATTGGGGCTCTAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15743.06 Da        Isoelectric Point: 4.7790

>AT58047 WP_053159226.1 NZ_CP013184:4277974-4278399 [Pseudomonas protegens]
MYDYAIRFEQDRAPGVAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASEPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT58047 NZ_CP013184:4277974-4278399 [Pseudomonas protegens]
ATGTACGACTACGCCATTCGCTTCGAGCAAGACCGTGCACCGGGAGTGGCGGTCTTCTGCCGCGATCTGCCCGAACTCAA
TAGCTTTGGCGATGATCCTGAGCACGCCATCAACCAGGCCATCGACGCGCTCGAAACCACGCTGTCCCTTTACGTCGACC
AGCGCCGCGCCATTCCCCCAGCCTCTGAGCCGCTACCAGGGGAACAGGTCATTCATTTGCCAATGGTGACCGTGGCCAAG
ATAGCGCTGTGGAACACGATGATGGAGCGGGACATGCGCAAGGCCGATCTATGCCGACTGCTCGGAATCCACCAGGCCCA
GGGAGATCGCCTGGTGGACTTTCTACACAGCTCCAAAATGGAACAGCTGGAAAATGCCCTCGCAGCCCTAGGTAAACGTC
TTGCAGTATCAGTGGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References