Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2574727..2575349 Replicon chromosome
Accession NZ_CP013184
Organism Pseudomonas protegens strain H78

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H78_RS11890 Protein ID WP_077935001.1
Coordinates 2575167..2575349 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H78_RS11885 Protein ID WP_077933771.1
Coordinates 2574727..2575128 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H78_RS11860 2571505..2571939 - 435 WP_015634968.1 hypothetical protein -
H78_RS11865 2571972..2572340 - 369 WP_077933769.1 antibiotic biosynthesis monooxygenase -
H78_RS11870 2572438..2572908 + 471 WP_169893999.1 MarR family winged helix-turn-helix transcriptional regulator -
H78_RS11875 2573354..2573860 - 507 Protein_2329 DUF1266 domain-containing protein -
H78_RS11880 2573932..2574144 - 213 WP_077935000.1 recombinase RecA -
H78_RS11885 2574727..2575128 - 402 WP_077933771.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H78_RS11890 2575167..2575349 - 183 WP_077935001.1 type II toxin-antitoxin system HicA family toxin Toxin
H78_RS11895 2575492..2576190 - 699 WP_047336258.1 arsenical resistance protein ArsH -
H78_RS11900 2576200..2576670 - 471 WP_077933772.1 arsenate reductase ArsC -
H78_RS11905 2576699..2577982 - 1284 WP_077933773.1 arsenic transporter -
H78_RS11910 2578003..2578350 - 348 WP_077933774.1 metalloregulator ArsR/SmtB family transcription factor -
H78_RS11915 2578580..2579134 + 555 WP_077933775.1 hypothetical protein -
H78_RS11920 2579341..2579772 - 432 WP_011060488.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2573153..2582962 9809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6798.01 Da        Isoelectric Point: 11.5631

>T58045 WP_077935001.1 NZ_CP013184:c2575349-2575167 [Pseudomonas protegens]
VQSRLLIKELEAAGWVLERVTGSHHLFQHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLL

Download         Length: 183 bp

>T58045 NZ_CP013184:c2575349-2575167 [Pseudomonas protegens]
GTGCAAAGCAGACTGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGAGTCACCGGCAGCCATCATCTGTT
CCAGCATCCCTACCGGCCCAACACCGTTCCCGTGCCGCATCCGAAGAAGGATCTGCCACGGGGAACGGTCCGGGCCATCA
GGAAACTGGCCGGGCTGCTCTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14514.49 Da        Isoelectric Point: 5.1222

>AT58045 WP_077933771.1 NZ_CP013184:c2575128-2574727 [Pseudomonas protegens]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAVEIAHLMLEELARAGQAIPLPSATQTHRAHPDYQGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVRAHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT58045 NZ_CP013184:c2575128-2574727 [Pseudomonas protegens]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACGGCCACCGGCATCCAGATTCCCGACATTCCCGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCCTACAGCGCCGCCGTCGAGATTGCCCACCTCATGCTCGAAGAGCTGGCCCGCG
CCGGGCAGGCCATTCCCCTGCCCTCTGCCACCCAAACGCACCGCGCCCATCCTGATTACCAGGGGATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCGGGGTACGTGATTCAGCAGAT
CGACCGCTTTGTCCGAGCGCACAACATCAAGAGCCGGTCGTCCTTTCTGGCGGATGCGGCGCTGGAAAAGCTCGGGCGCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References