Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 300153..300766 Replicon chromosome
Accession NZ_CP013184
Organism Pseudomonas protegens strain H78

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9LBG9
Locus tag H78_RS01345 Protein ID WP_041115175.1
Coordinates 300153..300335 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H78_RS01350 Protein ID WP_171820684.1
Coordinates 300332..300766 (+) Length 145 a.a.

Genomic Context

H78_RS01325H78_RS01340H78_RS01345H78_RS01350H78_RS01360H78_RS01365H78_RS01330H78_RS01335H78_RS01355
Location: 295891..297852 (1962 bp)
Type: Others
Protein ID: WP_161466434.1
Location: 299045..299935 (891 bp)
Type: Others
Protein ID: WP_011058633.1
Location: 300153..300335 (183 bp)
Type: Toxin
Protein ID: WP_041115175.1
Location: 300332..300766 (435 bp)
Type: Antitoxin
Protein ID: WP_171820684.1
Location: 302031..304289 (2259 bp)
Type: Others
Protein ID: WP_077933198.1
Location: 304433..305761 (1329 bp)
Type: Others
Protein ID: WP_077933199.1
Location: 297862..298119 (258 bp)
Type: Others
Protein ID: WP_015633747.1
Location: 298172..298912 (741 bp)
Type: Others
Protein ID: WP_019094920.1
Location: 300779..301825 (1047 bp)
Type: Others
Protein ID: WP_077933197.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H78_RS01325295891..297852+1962WP_161466434.1choline transporter BetT-
H78_RS01330297862..298119-258WP_015633747.1hypothetical protein-
H78_RS01335298172..298912-741WP_019094920.1SDR family oxidoreductase-
H78_RS01340299045..299935+891WP_011058633.1LysR family transcriptional regulator-
H78_RS01345300153..300335+183WP_041115175.1type II toxin-antitoxin system HicA family toxinToxin
H78_RS01350300332..300766+435WP_171820684.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
H78_RS01355300779..301825-1047WP_077933197.1LacI family DNA-binding transcriptional regulator-
H78_RS01360302031..304289+2259WP_077933198.1TonB-dependent receptor-
H78_RS01365304433..305761+1329WP_077933199.1LLM class flavin-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(14-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6866.97 Da        Isoelectric Point: 10.8547

>T58042 WP_041115175.1 NZ_CP013184:300153-300335 [Pseudomonas protegens]
MRSREMISRIEADGWYLVAVKGSHHQYKHPFKPGRVTIRHPDTDLPKGTLNSILKQAGLK

Download         Length: 183 bp

>T58042 NZ_CP013184:300153-300335 [Pseudomonas protegens]
ATGCGCAGTCGGGAAATGATCAGCAGGATCGAGGCGGATGGTTGGTACTTGGTGGCCGTCAAGGGCAGTCACCATCAGTA
CAAGCATCCTTTCAAGCCGGGCCGCGTGACCATCAGGCACCCGGATACGGATCTGCCCAAAGGCACGCTCAACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16003.82 Da        Isoelectric Point: 4.3449

>AT58042 WP_171820684.1 NZ_CP013184:300332-300766 [Pseudomonas protegens]
MSLFLNEESNDMKFPVVLHKDADSEYGVTVPDVPGCHSAGPTVSLAFENIKEALSLHYEGLVADGEPLPQVHEIDDHLDN
PDYAGGVWGVVEFDVTPYFGKSVRFNATLPEQLLERIDQRVERDQRYRSRSGFLAAAALRELSA

Download         Length: 435 bp

>AT58042 NZ_CP013184:300332-300766 [Pseudomonas protegens]
ATGAGCCTGTTTCTGAACGAGGAGTCCAACGACATGAAATTCCCGGTGGTTCTGCACAAGGATGCCGACTCCGAATATGG
GGTGACAGTTCCGGATGTACCGGGCTGCCATTCTGCCGGCCCGACGGTTTCCCTGGCGTTCGAGAACATCAAGGAAGCGC
TGTCCCTGCACTACGAGGGCCTGGTGGCGGACGGCGAGCCCTTGCCCCAGGTGCATGAGATTGACGATCACCTGGACAAC
CCCGACTACGCCGGTGGCGTATGGGGCGTGGTGGAGTTCGACGTGACGCCCTACTTCGGCAAGTCGGTGCGCTTCAACGC
CACCCTGCCGGAGCAATTGCTGGAGCGCATCGACCAGAGGGTCGAACGCGATCAGCGCTACCGTTCGCGTTCCGGGTTCC
TCGCCGCTGCGGCGCTGCGCGAGCTCTCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9LBG9

Antitoxin

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Source
ID
Structure
No matching records found

References