58032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2090996..2091510 Replicon chromosome
Accession NZ_CP013182
Organism Staphylococcus aureus strain SA40TW

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SA40TW_RS10830 Protein ID WP_000581792.1
Coordinates 2090996..2091205 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SA40TW_RS10835 Protein ID WP_000138934.1
Coordinates 2091217..2091510 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA40TW_RS10810 2086504..2087862 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SA40TW_RS10815 2087877..2088947 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
SA40TW_RS10820 2089265..2090467 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SA40TW_RS10825 2090731..2090868 - 138 WP_000828354.1 hypothetical protein -
SA40TW_RS10830 2090996..2091205 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SA40TW_RS10835 2091217..2091510 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SA40TW_RS10840 2091676..2093160 + 1485 WP_000571549.1 cardiolipin synthase -
SA40TW_RS10845 2093188..2093835 + 648 WP_001187610.1 HD domain-containing protein -
SA40TW_RS10855 2094650..2095522 - 873 WP_000725802.1 membrane protein insertase YidC -
SA40TW_RS10860 2095608..2096249 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T58032 WP_000581792.1 NZ_CP013182:c2091205-2090996 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T58032 NZ_CP013182:c2091205-2090996 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT58032 WP_000138934.1 NZ_CP013182:c2091510-2091217 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT58032 NZ_CP013182:c2091510-2091217 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References