Detailed information of TA system TA058025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 855958..856490
• Replicon: chromosome
• Accession: NZ_CP013182
• Organism: Staphylococcus aureus strain SA40TW

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: SA40TW_RS04315
• Protein ID: WP_001103942.1
• Coordinates: 856170..856490 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: SA40TW_RS04310
• Protein ID: WP_001058486.1
• Coordinates: 855958..856167 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA40TW_RS04265	850977..852197	-	1221	WP_000266157.1	site-specific integrase	-
SA40TW_RS04270	852286..853014	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
SA40TW_RS04275	853038..853766	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
SA40TW_RS04280	853836..854267	-	432	WP_001228759.1	hypothetical protein	-
SA40TW_RS04285	854284..854742	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
SA40TW_RS04290	854754..855086	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
SA40TW_RS04295	855279..855542	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
SA40TW_RS04300	855535..855807	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
SA40TW_RS04305	855819..855965	+	147	WP_000784875.1	hypothetical protein	-
SA40TW_RS04310	855958..856167	+	210	WP_001058486.1	hypothetical protein	Antitoxin
SA40TW_RS04315	856170..856490	+	321	WP_001103942.1	DUF1474 family protein	Toxin
SA40TW_RS04320	856554..857423	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
SA40TW_RS04325	857440..858909	+	1470	WP_000390454.1	virulence-associated E family protein	-
SA40TW_RS04335	859195..859557	+	363	WP_001039168.1	hypothetical protein	-
SA40TW_RS04340	859559..859843	+	285	WP_000998181.1	hypothetical protein	-
SA40TW_RS04345	859840..860481	+	642	WP_021758233.1	pathogenicity island protein	-
SA40TW_RS04350	860998..861339	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	832943..866290	33347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T58025 WP_001103942.1 NZ_CP013182:856170-856490 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T58025 NZ_CP013182:856170-856490 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT58025 WP_001058486.1 NZ_CP013182:855958-856167 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT58025 NZ_CP013182:855958-856167 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4