Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 838263..838740 Replicon chromosome
Accession NZ_CP013182
Organism Staphylococcus aureus strain SA40TW

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA40TW_RS04155 Protein ID WP_000052076.1
Coordinates 838263..838451 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA40TW_RS04160 Protein ID WP_001059690.1
Coordinates 838480..838740 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA40TW_RS04125 834301..834771 + 471 WP_000824462.1 hypothetical protein -
SA40TW_RS04130 835112..835798 + 687 WP_001823812.1 thermonuclease family protein -
SA40TW_RS04135 836155..836355 + 201 WP_001059082.1 cold-shock protein -
SA40TW_RS04140 836854..837072 - 219 WP_000005888.1 hypothetical protein -
SA40TW_RS04145 837134..837418 - 285 WP_001004397.1 hypothetical protein -
SA40TW_RS04150 837506..838075 - 570 WP_001106657.1 hypothetical protein -
SA40TW_RS04155 838263..838451 - 189 WP_000052076.1 hypothetical protein Toxin
SA40TW_RS04160 838480..838740 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA40TW_RS04165 839081..839284 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA40TW_RS04170 839281..839517 - 237 WP_000368687.1 hypothetical protein -
SA40TW_RS04175 839742..840323 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
SA40TW_RS04180 840396..841013 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
SA40TW_RS04185 841169..841663 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SA40TW_RS04190 842062..842484 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SA40TW_RS04195 842632..843348 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 832943..866290 33347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T58024 WP_000052076.1 NZ_CP013182:c838451-838263 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T58024 NZ_CP013182:c838451-838263 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT58024 WP_001059690.1 NZ_CP013182:c838740-838480 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT58024 NZ_CP013182:c838740-838480 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References