Detailed information of TA system TA058023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 123..600
• Replicon: plasmid 2
• Accession: NZ_CP013180
• Organism: Aeromonas hydrophila strain JBN2301

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: AS145_RS24330
• Protein ID: WP_173664817.1
• Coordinates: 331..600 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A806XTE1
• Locus tag: AS145_RS23215
• Protein ID: WP_059296381.1
• Coordinates: 123..347 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AS145_RS23215	123..347	+	225	WP_059296381.1	TraY domain-containing protein	Antitoxin
AS145_RS24330	331..600	+	270	WP_173664817.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AS145_RS23220	695..1750	+	1056	WP_060615919.1	hypothetical protein	-
AS145_RS23225	2484..3449	+	966	WP_059296376.1	replication initiation protein	-
AS145_RS23230	3562..3885	-	324	WP_059296377.1	hypothetical protein	-
AS145_RS23235	4095..4505	+	411	WP_059296378.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..6162	6162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 11553.68 Da
• Isoelectric Point: 12.7493

>T58023 WP_173664817.1 NZ_CP013180:331-600 [Aeromonas hydrophila]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Nucleotide

• Length: 270 bp

>T58023 NZ_CP013180:331-600 [Aeromonas hydrophila]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 9631.07 Da
• Isoelectric Point: 12.6692

>AT58023 WP_059296381.1 NZ_CP013180:123-347 [Aeromonas hydrophila]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 225 bp

>AT58023 NZ_CP013180:123-347 [Aeromonas hydrophila]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A806XTE1