Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3902250..3902782 Replicon chromosome
Accession NZ_CP013145
Organism Colwellia sp. MT41

Toxin (Protein)


Gene name parE Uniprot ID A0A1Z5I4P0
Locus tag CMT41_RS16510 Protein ID WP_057182825.1
Coordinates 3902489..3902782 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z5I4P5
Locus tag CMT41_RS16505 Protein ID WP_057182824.1
Coordinates 3902250..3902489 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CMT41_RS16495 3899276..3901798 + 2523 WP_198149759.1 TonB-dependent receptor -
CMT41_RS16505 3902250..3902489 + 240 WP_057182824.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CMT41_RS16510 3902489..3902782 + 294 WP_057182825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CMT41_RS16515 3902888..3903160 - 273 WP_058027873.1 hypothetical protein -
CMT41_RS16520 3903273..3903575 - 303 WP_143760114.1 hypothetical protein -
CMT41_RS16525 3903705..3904238 - 534 WP_058027874.1 hypothetical protein -
CMT41_RS16530 3904617..3905591 - 975 WP_058027875.1 hypothetical protein -
CMT41_RS16535 3905679..3906011 - 333 Protein_3277 toll/interleukin-1 receptor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11430.27 Da        Isoelectric Point: 9.5603

>T58020 WP_057182825.1 NZ_CP013145:3902489-3902782 [Colwellia sp. MT41]
MSKFLLSSKAKSDLIKIAKYTQLTWGKSQRNDYLKILDNTFRFLADEPELGINCDYIRECYNKYPQASHVIYYKEHKVNQ
ILIVRILHKSMDVNSAL

Download         Length: 294 bp

>T58020 NZ_CP013145:3902489-3902782 [Colwellia sp. MT41]
ATGAGTAAGTTTTTATTATCTTCGAAAGCAAAGTCAGATTTAATTAAAATAGCTAAATATACCCAATTAACTTGGGGGAA
ATCACAGAGAAATGATTATTTAAAAATACTGGATAATACCTTTCGATTTTTAGCCGATGAACCAGAGTTAGGTATTAATT
GCGATTATATTAGAGAATGCTACAACAAGTACCCTCAAGCCAGCCATGTAATTTATTACAAAGAGCATAAAGTTAATCAA
ATTTTAATCGTGCGTATATTGCATAAAAGTATGGATGTAAACTCCGCACTCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8871.87 Da        Isoelectric Point: 4.7164

>AT58020 WP_057182824.1 NZ_CP013145:3902250-3902489 [Colwellia sp. MT41]
MAKNTSVTLGDHFDQFIKQQLNTGRYGSASEIVRAGLRALEDQEAKLLNLRNMLIQGEQSGIADYSYESLLTELDKDNH

Download         Length: 240 bp

>AT58020 NZ_CP013145:3902250-3902489 [Colwellia sp. MT41]
ATGGCTAAAAACACAAGCGTAACATTGGGCGATCATTTTGATCAATTTATAAAGCAACAACTTAACACTGGTCGTTATGG
CTCAGCAAGTGAAATTGTTAGAGCTGGATTAAGAGCTTTAGAAGATCAAGAAGCCAAGCTATTAAATTTACGCAATATGC
TAATCCAAGGTGAACAAAGCGGCATTGCAGATTACAGTTATGAAAGTTTATTAACCGAGCTAGATAAAGATAACCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z5I4P0

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z5I4P5

References