Detailed information of TA system TA058019

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 2483340..2484135
• Replicon: chromosome
• Accession: NZ_CP013145
• Organism: Colwellia sp. MT41

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: CMT41_RS10585
• Protein ID: WP_058027226.1
• Coordinates: 2483340..2483747 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: CMT41_RS10590
• Protein ID: WP_058027227.1
• Coordinates: 2483749..2484135 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CMT41_RS10570	2479058..2480026	+	969	WP_058027223.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
CMT41_RS10575	2480414..2481772	+	1359	WP_058027224.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
CMT41_RS10580	2481812..2482936	+	1125	WP_058027225.1	hypothetical protein	-
CMT41_RS10585	2483340..2483747	-	408	WP_058027226.1	DUF86 domain-containing protein	Toxin
CMT41_RS10590	2483749..2484135	-	387	WP_058027227.1	nucleotidyltransferase domain-containing protein	Antitoxin
CMT41_RS10595	2484327..2485226	-	900	WP_083494269.1	UTP--glucose-1-phosphate uridylyltransferase GalU	-
CMT41_RS10605	2485883..2486599	-	717	WP_058027230.1	WecB/TagA/CpsF family glycosyltransferase	-
CMT41_RS10610	2486587..2487651	-	1065	WP_058027231.1	glycosyltransferase family 4 protein	-
CMT41_RS10615	2487781..2488824	-	1044	WP_058027232.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (13-131)

Antitoxin

• Polymerase beta, nucleotidyltransferase (8-97)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15224.43 Da
• Isoelectric Point: 6.0822

>T58019 WP_058027226.1 NZ_CP013145:c2483747-2483340 [Colwellia sp. MT41]
MDDVLVNKLSTITRCLKRIREVYAEAGDNFSHDYTRQDSVILNLQRACEASIDIANYLNKNKQLAIPQSSRDSFQILTSA
GLISSSVATNLKKMIGLGNIAVHDYKELNMDIVEAVINHHLVDFELFISEIKKEL

Nucleotide

• Length: 408 bp

>T58019 NZ_CP013145:c2483747-2483340 [Colwellia sp. MT41]
ATGGATGATGTTTTAGTAAATAAATTATCGACGATTACTCGTTGCTTAAAGCGTATTCGTGAAGTTTATGCGGAAGCAGG
GGATAACTTCTCTCATGATTATACCCGGCAGGACTCTGTTATTTTAAATTTGCAACGTGCTTGTGAAGCTTCTATTGATA
TTGCTAATTATTTGAATAAAAATAAGCAATTGGCAATACCGCAAAGTAGTCGTGATAGCTTTCAAATTCTGACTTCTGCA
GGACTTATTTCATCATCTGTGGCGACTAATTTAAAGAAGATGATTGGACTAGGTAATATAGCGGTTCATGACTATAAAGA
GTTAAATATGGATATTGTAGAAGCGGTAATTAACCATCACCTGGTCGACTTTGAATTATTTATTAGTGAAATTAAGAAAG
AGCTTTAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14618.70 Da
• Isoelectric Point: 4.4325

>AT58019 WP_058027227.1 NZ_CP013145:c2484135-2483749 [Colwellia sp. MT41]
MVIDLNTQLITALKQYFPDIKLLYLFGSHVSNQAHKNSDIDLAVLLANKISTVTRWEIQQELAVEFNVDVDLIDLLSAST
VMQNEIVNKGNCLYDAKDYKGEFEMQVMSMYQHLNEERSSLLTAFKGE

Nucleotide

• Length: 387 bp

>AT58019 NZ_CP013145:c2484135-2483749 [Colwellia sp. MT41]
ATGGTCATTGATCTTAATACTCAGCTTATTACTGCCCTTAAACAGTATTTTCCTGATATAAAACTGTTATATTTATTTGG
TTCTCATGTGAGTAATCAAGCTCACAAAAACAGTGATATTGATTTAGCTGTGTTGTTAGCAAATAAGATCTCTACGGTAA
CTCGTTGGGAAATACAGCAAGAATTAGCGGTAGAATTTAATGTCGATGTCGATTTAATTGATTTATTATCCGCTTCGACA
GTGATGCAAAATGAAATTGTTAATAAAGGCAATTGTTTGTATGATGCTAAGGATTATAAGGGCGAATTTGAAATGCAAGT
AATGTCTATGTATCAGCATTTAAATGAAGAACGGTCATCGTTATTAACGGCATTTAAAGGAGAATGA