Detailed information of TA system TA058016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 864002..864530
• Replicon: chromosome
• Accession: NZ_CP013145
• Organism: Colwellia sp. MT41

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CMT41_RS03670
• Protein ID: WP_058026397.1
• Coordinates: 864246..864530 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Z5I1C9
• Locus tag: CMT41_RS03665
• Protein ID: WP_057179831.1
• Coordinates: 864002..864256 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CMT41_RS03650	859088..860740	+	1653	WP_058028130.1	alpha-glucosidase family protein	-
CMT41_RS03655	860790..862592	+	1803	WP_058026395.1	alpha-amylase	-
CMT41_RS03660	862851..863651	-	801	WP_083494205.1	aldo/keto reductase	-
CMT41_RS03665	864002..864256	+	255	WP_057179831.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CMT41_RS03670	864246..864530	+	285	WP_058026397.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CMT41_RS03675	864857..865831	-	975	WP_058026398.1	hypothetical protein	-
CMT41_RS03680	865923..866357	+	435	Protein_729	IS1595 family transposase	-
CMT41_RS03685	866614..867162	-	549	WP_088568917.1	TrmH family RNA methyltransferase	-
CMT41_RS03690	867585..868004	+	420	WP_057179835.1	hypothetical protein	-
CMT41_RS19315	868181..868291	+	111	WP_198149782.1	adenylyltransferase/cytidyltransferase family protein	-
CMT41_RS19320	868281..868472	+	192	WP_198149783.1	hypothetical protein	-
CMT41_RS03700	868703..869164	-	462	WP_058026400.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	866010..866357	347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11180.24 Da
• Isoelectric Point: 10.7103

>T58016 WP_058026397.1 NZ_CP013145:864246-864530 [Colwellia sp. MT41]
MTYKLVFKQDAMKEWEKLDSTIREQFKKKLIERLANPRIDSARLNGMKDCYKIKLRSAGYRLVYQVRDSEILISVVAVGK
RDRNQVYKIAIKRI

Nucleotide

• Length: 285 bp

>T58016 NZ_CP013145:864246-864530 [Colwellia sp. MT41]
ATGACCTATAAGCTTGTTTTTAAGCAAGATGCGATGAAAGAGTGGGAGAAATTAGATTCCACAATTAGAGAGCAATTCAA
GAAAAAATTAATTGAAAGATTAGCAAATCCACGCATAGATTCAGCTAGATTAAATGGAATGAAGGATTGCTACAAGATTA
AGTTACGTAGTGCAGGTTATAGATTAGTTTATCAAGTGCGTGATAGTGAGATATTAATATCAGTTGTTGCCGTAGGTAAA
CGTGATCGTAATCAAGTTTATAAAATTGCAATTAAACGAATTTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9443.89 Da
• Isoelectric Point: 4.1225

>AT58016 WP_057179831.1 NZ_CP013145:864002-864256 [Colwellia sp. MT41]
MQTIRPILADNSTSISELKKNPMAVVEQGDGFPVAVLNRNQPVFYCVPAAAYELMMDKLEDIELALIVKERQNQPEIEVN
INDL

Nucleotide

• Length: 255 bp

>AT58016 NZ_CP013145:864002-864256 [Colwellia sp. MT41]
ATGCAAACAATTAGACCAATATTAGCTGATAACTCTACTAGCATAAGTGAGTTGAAAAAAAACCCAATGGCTGTTGTTGA
ACAAGGTGATGGTTTTCCTGTTGCGGTATTAAACAGAAACCAACCAGTTTTTTATTGTGTTCCTGCTGCTGCTTATGAAC
TCATGATGGACAAACTAGAAGATATAGAACTAGCGTTAATTGTTAAAGAACGTCAAAACCAACCTGAAATAGAGGTTAAC
ATTAATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z5I1C9