Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3977522..3978123 Replicon chromosome
Accession NZ_CP013141
Organism Lysobacter antibioticus strain ATCC 29479

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GLA29479_RS23800 Protein ID WP_144436553.1
Coordinates 3977522..3977779 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GLA29479_RS16065 Protein ID WP_057972177.1
Coordinates 3977776..3978123 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLA29479_RS16035 3973563..3974252 + 690 WP_057972171.1 polysaccharide deacetylase family protein -
GLA29479_RS16040 3974284..3974682 - 399 WP_057972172.1 hypothetical protein -
GLA29479_RS25600 3974766..3975062 - 297 Protein_3238 hypothetical protein -
GLA29479_RS16050 3975690..3976184 + 495 WP_057972174.1 hypothetical protein -
GLA29479_RS16055 3976271..3976633 + 363 WP_057972175.1 VOC family protein -
GLA29479_RS16060 3976851..3977183 + 333 WP_057972176.1 hypothetical protein -
GLA29479_RS23800 3977522..3977779 + 258 WP_144436553.1 type II toxin-antitoxin system HicA family toxin Toxin
GLA29479_RS16065 3977776..3978123 + 348 WP_057972177.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GLA29479_RS16070 3978618..3978863 - 246 WP_057972178.1 YegP family protein -
GLA29479_RS23810 3979932..3980099 + 168 WP_082638743.1 periplasmic nitrate reductase, NapE protein -
GLA29479_RS16080 3980346..3980648 + 303 WP_057972179.1 chaperone NapD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(58-106)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9481.98 Da        Isoelectric Point: 10.4820

>T58015 WP_144436553.1 NZ_CP013141:3977522-3977779 [Lysobacter antibioticus]
VSKKHKKTITKIFARPMSGSIKWADIESLFVSYLGAEKEEREGSRVAFILNGQVHLFHRPHPSPDTDKGAVARVKKILED
LGVSP

Download         Length: 258 bp

>T58015 NZ_CP013141:3977522-3977779 [Lysobacter antibioticus]
GTGTCTAAAAAGCACAAGAAGACGATCACAAAGATCTTCGCCAGGCCCATGTCTGGGTCCATCAAGTGGGCCGACATCGA
GTCGCTTTTTGTCAGCTACCTAGGCGCAGAAAAGGAAGAGCGCGAAGGCTCTCGCGTTGCATTCATCTTGAATGGCCAAG
TGCACTTATTTCACAGACCTCACCCGAGCCCTGACACTGACAAAGGCGCAGTGGCCAGAGTGAAGAAAATTCTCGAAGAC
CTTGGGGTGTCCCCATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12727.51 Da        Isoelectric Point: 6.7139

>AT58015 WP_057972177.1 NZ_CP013141:3977776-3978123 [Lysobacter antibioticus]
MTKTNVMKFGNYFATVSYDPEIEMFRGEFVSLNGGADFYAASVRELRAEGQASLDAFLAICKERKISPHKAFSGKLQLRL
KKATHERATIAAAARGVSLNNLIEEAVEHELEECA

Download         Length: 348 bp

>AT58015 NZ_CP013141:3977776-3978123 [Lysobacter antibioticus]
ATGACCAAAACCAATGTAATGAAGTTCGGAAACTACTTCGCAACGGTCTCGTACGATCCAGAAATCGAGATGTTCCGCGG
GGAGTTCGTTAGCTTGAACGGAGGTGCTGATTTCTATGCGGCTTCCGTTCGTGAACTTCGCGCCGAGGGTCAGGCGTCTC
TGGATGCGTTCCTGGCCATCTGTAAAGAGCGTAAAATCTCCCCACACAAAGCCTTCTCAGGGAAGCTTCAACTGCGACTG
AAAAAGGCTACGCATGAACGCGCCACAATTGCGGCGGCGGCGCGCGGCGTGAGCCTCAACAATTTGATTGAAGAAGCTGT
AGAGCACGAACTGGAAGAGTGTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References