Detailed information of TA system TA058009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2660334..2660872
• Replicon: chromosome
• Accession: NZ_CP013137
• Organism: Staphylococcus aureus strain XQ

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: ASU36_RS13520
• Protein ID: WP_000383747.1
• Coordinates: 2660546..2660872 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A0H3JSN0
• Locus tag: ASU36_RS13515
• Protein ID: WP_001058495.1
• Coordinates: 2660334..2660543 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASU36_RS13475	2655414..2655656	+	243	WP_000897044.1	30S ribosomal protein S18	-
ASU36_RS13480	2655988..2656614	-	627	WP_000281092.1	hypothetical protein	-
ASU36_RS13485	2656601..2657298	-	698	Protein_2547	DUF3800 domain-containing protein	-
ASU36_RS13490	2657301..2658515	-	1215	WP_000270126.1	site-specific integrase	-
ASU36_RS13495	2658814..2659548	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
ASU36_RS13500	2659698..2659910	+	213	WP_001063624.1	helix-turn-helix transcriptional regulator	-
ASU36_RS13505	2659911..2660183	+	273	WP_001138298.1	helix-turn-helix domain-containing protein	-
ASU36_RS13510	2660195..2660341	+	147	WP_000784887.1	hypothetical protein	-
ASU36_RS13515	2660334..2660543	+	210	WP_001058495.1	hypothetical protein	Antitoxin
ASU36_RS13520	2660546..2660872	+	327	WP_000383747.1	DUF1474 family protein	Toxin
ASU36_RS13525	2660937..2661806	+	870	WP_058008337.1	primase alpha helix C-terminal domain-containing protein	-
ASU36_RS13530	2661820..2663529	+	1710	WP_000447469.1	DUF927 domain-containing protein	-
ASU36_RS13535	2663839..2664219	+	381	WP_058008339.1	hypothetical protein	-
ASU36_RS13540	2664216..2664857	+	642	WP_001047698.1	hypothetical protein	-
ASU36_RS13545	2665307..2665648	+	342	WP_001190614.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb	2655988..2676193	20205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12985.33 Da
• Isoelectric Point: 4.3050

>T58009 WP_000383747.1 NZ_CP013137:2660546-2660872 [Staphylococcus aureus]
MDWEIKSLFSDLKLLKDSFEDLKDSKGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T58009 NZ_CP013137:2660546-2660872 [Staphylococcus aureus]
ATGGATTGGGAAATTAAAAGTTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAAGGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8206.22 Da
• Isoelectric Point: 4.3718

>AT58009 WP_001058495.1 NZ_CP013137:2660334-2660543 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT58009 NZ_CP013137:2660334-2660543 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3JSN0