Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1645791..1646305 Replicon chromosome
Accession NZ_CP013137
Organism Staphylococcus aureus strain XQ

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ASU36_RS08465 Protein ID WP_000581792.1
Coordinates 1645791..1646000 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ASU36_RS08470 Protein ID WP_000138932.1
Coordinates 1646012..1646305 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASU36_RS08445 1641298..1642657 - 1360 Protein_1602 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ASU36_RS08450 1642672..1643742 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ASU36_RS08455 1644060..1645262 + 1203 WP_001109939.1 rod shape-determining protein RodA -
ASU36_RS08460 1645526..1645663 - 138 WP_000828354.1 hypothetical protein -
ASU36_RS08465 1645791..1646000 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ASU36_RS08470 1646012..1646305 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ASU36_RS08475 1646471..1647955 + 1485 WP_000571551.1 cardiolipin synthase -
ASU36_RS08480 1647983..1648630 + 648 WP_001187620.1 HD domain-containing protein -
ASU36_RS08485 1649261..1650133 - 873 WP_000725802.1 membrane protein insertase YidC -
ASU36_RS08490 1650219..1650860 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T58002 WP_000581792.1 NZ_CP013137:c1646000-1645791 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T58002 NZ_CP013137:c1646000-1645791 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACGCCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT58002 WP_000138932.1 NZ_CP013137:c1646305-1646012 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT58002 NZ_CP013137:c1646305-1646012 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAAGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References