Detailed information of TA system TA057996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 1041693..1042481
• Replicon: chromosome
• Accession: NZ_CP013137
• Organism: Staphylococcus aureus strain XQ

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2I7Y5B3
• Locus tag: ASU36_RS05150
• Protein ID: WP_000525004.1
• Coordinates: 1042020..1042481 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASU36_RS05145
• Protein ID: WP_058008071.1
• Coordinates: 1041693..1042007 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASU36_RS05085	1036835..1038001	-	1167	WP_058008068.1	DUF2800 domain-containing protein	-
ASU36_RS05090	1037998..1038360	-	363	WP_000985984.1	hypothetical protein	-
ASU36_RS05095	1038375..1038698	-	324	WP_031773431.1	hypothetical protein	-
ASU36_RS05100	1038777..1038938	-	162	WP_001285955.1	DUF1270 family protein	-
ASU36_RS05105	1038951..1039214	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
ASU36_RS05110	1039239..1039454	-	216	WP_001097552.1	hypothetical protein	-
ASU36_RS05115	1039509..1039874	+	366	WP_001128433.1	hypothetical protein	-
ASU36_RS05120	1039843..1040088	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
ASU36_RS05125	1040144..1040353	+	210	WP_000642492.1	hypothetical protein	-
ASU36_RS05130	1040343..1040486	-	144	WP_000939498.1	hypothetical protein	-
ASU36_RS05135	1040515..1041291	-	777	WP_001148544.1	Rha family transcriptional regulator	-
ASU36_RS05140	1041305..1041541	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
ASU36_RS05145	1041693..1042007	+	315	WP_058008071.1	helix-turn-helix domain-containing protein	Antitoxin
ASU36_RS05150	1042020..1042481	+	462	WP_000525004.1	hypothetical protein	Toxin
ASU36_RS05155	1042499..1043083	+	585	WP_000825948.1	hypothetical protein	-
ASU36_RS05160	1043313..1043459	+	147	WP_001013104.1	hypothetical protein	-
ASU36_RS05165	1043456..1044069	-	614	Protein_1003	ATPase	-
ASU36_RS05170	1044195..1045400	+	1206	WP_000264748.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / gnd	997030..1067996	70966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18074.46 Da
• Isoelectric Point: 4.6915

>T57996 WP_000525004.1 NZ_CP013137:1042020-1042481 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T57996 NZ_CP013137:1042020-1042481 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12062.62 Da
• Isoelectric Point: 8.0143

>AT57996 WP_058008071.1 NZ_CP013137:1041693-1042007 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEKNDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT57996 NZ_CP013137:1041693-1042007 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAAAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A2I7Y5B3