Detailed information of TA system TA057992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 297104..297581
• Replicon: chromosome
• Accession: NZ_CP013137
• Organism: Staphylococcus aureus strain XQ

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: ASU36_RS01450
• Protein ID: WP_000052076.1
• Coordinates: 297104..297292 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: ASU36_RS01455
• Protein ID: WP_058007934.1
• Coordinates: 297321..297581 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASU36_RS01420	293131..293613	+	483	WP_000824492.1	hypothetical protein	-
ASU36_RS01425	293954..294640	+	687	WP_000141556.1	thermonuclease family protein	-
ASU36_RS01430	294997..295197	+	201	WP_001059082.1	cold-shock protein	-
ASU36_RS01435	295695..295913	-	219	WP_000005883.1	hypothetical protein	-
ASU36_RS01440	295975..296259	-	285	WP_001004397.1	hypothetical protein	-
ASU36_RS01445	296347..296916	-	570	WP_001106648.1	hypothetical protein	-
ASU36_RS01450	297104..297292	-	189	WP_000052076.1	hypothetical protein	Toxin
ASU36_RS01455	297321..297581	-	261	WP_058007934.1	hypothetical protein	Antitoxin
ASU36_RS01460	297922..298125	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
ASU36_RS01465	298122..298357	-	236	Protein_286	hypothetical protein	-
ASU36_RS01470	298582..299163	+	582	WP_001140691.1	phosphoglycerate mutase family protein	-
ASU36_RS01475	299236..299853	-	618	WP_000954354.1	LysE/ArgO family amino acid transporter	-
ASU36_RS01480	300010..300504	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
ASU36_RS01485	300901..301323	-	423	WP_058007936.1	organic hydroperoxide resistance protein	-
ASU36_RS01490	301471..302187	+	717	WP_031927536.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T57992 WP_000052076.1 NZ_CP013137:c297292-297104 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T57992 NZ_CP013137:c297292-297104 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9926.06 Da
• Isoelectric Point: 4.0624

>AT57992 WP_058007934.1 NZ_CP013137:c297581-297321 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTVAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT57992 NZ_CP013137:c297581-297321 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCGTTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18