Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2202907..2203504 Replicon chromosome
Accession NZ_CP013136
Organism Herbaspirillum seropedicae strain AU14040

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag hsc_RS09675 Protein ID WP_069373785.1
Coordinates 2203322..2203504 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag hsc_RS09670 Protein ID WP_069373784.1
Coordinates 2202907..2203302 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
hsc_RS09645 2198593..2200233 + 1641 WP_013233959.1 Kef family K(+) transporter -
hsc_RS09650 2200584..2201093 + 510 WP_013233960.1 6,7-dimethyl-8-ribityllumazine synthase -
hsc_RS09655 2201258..2201575 + 318 WP_041310545.1 hypothetical protein -
hsc_RS09660 2201688..2202245 - 558 WP_013233962.1 DUF2242 domain-containing protein -
hsc_RS09665 2202541..2202762 + 222 WP_041310548.1 hypothetical protein -
hsc_RS09670 2202907..2203302 - 396 WP_069373784.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
hsc_RS09675 2203322..2203504 - 183 WP_069373785.1 type II toxin-antitoxin system HicA family toxin Toxin
hsc_RS09685 2203995..2204861 + 867 WP_013233963.1 alpha/beta hydrolase -
hsc_RS09690 2204952..2205302 + 351 WP_013233964.1 RidA family protein -
hsc_RS09695 2205309..2207558 + 2250 WP_069373786.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6620.77 Da        Isoelectric Point: 10.9178

>T57987 WP_069373785.1 NZ_CP013136:c2203504-2203322 [Herbaspirillum seropedicae]
MDSAALIKRLKADGWYLAHTVGSHHQFKHPTKPGKVTLPHPKKDLPLATQNSILKQAGLK

Download         Length: 183 bp

>T57987 NZ_CP013136:c2203504-2203322 [Herbaspirillum seropedicae]
ATGGACAGCGCAGCCCTCATCAAACGACTCAAGGCCGACGGCTGGTACCTGGCGCATACAGTAGGCTCGCACCACCAGTT
CAAGCATCCGACCAAGCCCGGCAAGGTGACGTTGCCACATCCCAAGAAGGATCTGCCCTTGGCCACGCAGAACAGCATTC
TCAAGCAAGCGGGCCTGAAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14487.23 Da        Isoelectric Point: 4.5011

>AT57987 WP_069373784.1 NZ_CP013136:c2203302-2202907 [Herbaspirillum seropedicae]
MLYPLYVHKDAESAYGAAFPDFPGCFAAADELRDLPAAAQEAVEAHFHGQTEPIPDPSAPEEWADDERFQGGYWMLVEID
LSRVNAKSVRLNVSLPQNLVARIDSVAQARRMSRSAFLALAAEHEMQSGIR

Download         Length: 396 bp

>AT57987 NZ_CP013136:c2203302-2202907 [Herbaspirillum seropedicae]
ATGCTCTATCCTCTCTACGTCCACAAGGATGCCGAAAGTGCCTATGGCGCTGCCTTCCCTGATTTCCCCGGCTGCTTCGC
CGCAGCGGACGAACTGCGGGATCTACCTGCCGCCGCGCAGGAGGCAGTGGAGGCGCATTTCCATGGTCAAACCGAGCCTA
TCCCCGACCCGAGCGCTCCCGAGGAATGGGCCGACGATGAACGATTCCAGGGCGGTTACTGGATGCTGGTGGAAATCGAT
TTGTCACGGGTGAACGCCAAGTCAGTACGACTCAACGTCAGCCTGCCGCAGAACCTGGTGGCGCGCATCGATTCCGTGGC
ACAGGCGCGACGCATGTCACGCTCGGCCTTCCTGGCGCTGGCGGCCGAGCATGAAATGCAGAGCGGAATCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References