Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 430503..432133 Replicon chromosome
Accession NZ_CP013136
Organism Herbaspirillum seropedicae strain AU14040

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag hsc_RS01940 Protein ID WP_069372888.1
Coordinates 430772..432133 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag hsc_RS01935 Protein ID WP_013232456.1
Coordinates 430503..430772 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
hsc_RS01910 425582..426979 - 1398 WP_041310025.1 M23 family metallopeptidase -
hsc_RS01915 427237..428487 + 1251 WP_069372884.1 tyrosine--tRNA ligase -
hsc_RS01920 428500..428973 + 474 WP_069372885.1 D-tyrosyl-tRNA(Tyr) deacylase -
hsc_RS01925 429060..429707 + 648 WP_069372886.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
hsc_RS01930 429717..430361 + 645 WP_069372887.1 histidine phosphatase family protein -
hsc_RS01935 430503..430772 + 270 WP_013232456.1 helix-turn-helix domain-containing protein Antitoxin
hsc_RS01940 430772..432133 + 1362 WP_069372888.1 type II toxin-antitoxin system HipA family toxin Toxin
hsc_RS01945 432297..433319 + 1023 WP_069372889.1 tRNA dihydrouridine synthase DusB -
hsc_RS01950 433498..433731 + 234 WP_006463627.1 Fis family transcriptional regulator -
hsc_RS01955 433829..435400 + 1572 WP_069372890.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
hsc_RS01960 435512..436555 - 1044 WP_013232460.1 MerR family transcriptional regulator -
hsc_RS23750 436650..436829 + 180 WP_083247018.1 DUF2256 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(156-412)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 50019.81 Da        Isoelectric Point: 7.7495

>T57986 WP_069372888.1 NZ_CP013136:430772-432133 [Herbaspirillum seropedicae]
MSRRRKPKELGLWMNGSFVGTWALTAQGDSLQYDARWVVSASGRPLSLSLPFRPGNPPHRGDLVRHYFENLLPDSKAIRE
RLARRYQAADTDAFALLGEAGRDCVGALQILPLGATPELSWTIDARPLREREVAELLRQTMEPTPLALTQGEELRLSIAG
AQEKTALLRYLDQWCLPHGATPTTHILKLPMGLVGGLQLDLRHSVENEWLCSRILAAYGMPVAACDILCFEDQKVLAVER
FDRRWSRDPASGQAMLLRLPQEDMCQATGISPWLKYEADGGPGMKEIMALLGGAIDPVAARRHFFKAQLLFWMLWATDGH
AKNFSLFLKAGGRYEPTPLYDVLSVFPLIGEGPGKLSPHRAAMAMAVRAKNAHRKMKDILPRHWMALGSHFGIVAENGDG
PLAILEELAEQTEQVIAKVQADLPPGFPSELAASILDGLRRSASSLLSFVQTA

Download         Length: 1362 bp

>T57986 NZ_CP013136:430772-432133 [Herbaspirillum seropedicae]
ATGTCACGCCGCCGCAAGCCGAAGGAGCTCGGTCTGTGGATGAATGGCAGTTTCGTGGGGACCTGGGCGCTGACAGCGCA
AGGAGACAGCCTGCAATACGACGCCCGCTGGGTCGTCTCCGCCAGCGGCCGGCCATTGTCGCTTTCCCTTCCTTTCCGGC
CGGGCAATCCCCCCCATCGCGGCGACCTTGTCAGGCATTATTTCGAAAACCTGCTGCCTGACAGCAAAGCCATTCGCGAG
CGACTGGCACGCCGTTACCAGGCAGCCGATACCGATGCCTTCGCCCTGCTGGGCGAAGCCGGCCGCGATTGCGTGGGGGC
CTTGCAGATATTGCCCCTTGGCGCCACGCCTGAGCTGTCCTGGACCATTGACGCCCGCCCCTTGCGTGAACGGGAGGTGG
CCGAACTGCTGCGCCAGACCATGGAACCGACGCCCCTGGCCCTGACCCAGGGCGAAGAGTTGCGGCTTTCCATTGCCGGC
GCCCAGGAAAAGACCGCCTTGCTGCGTTACCTTGACCAATGGTGTTTGCCGCATGGCGCCACGCCTACCACCCATATCCT
GAAACTGCCCATGGGCCTGGTTGGCGGGCTCCAGCTCGATTTGCGCCATTCGGTCGAGAATGAGTGGCTGTGCTCACGCA
TCCTCGCCGCGTATGGGATGCCGGTCGCCGCCTGTGACATCCTCTGTTTCGAAGACCAGAAGGTGCTGGCGGTGGAACGC
TTCGACCGCCGCTGGAGCCGGGACCCCGCGAGCGGCCAGGCCATGCTGCTGCGCTTGCCGCAAGAAGACATGTGCCAGGC
TACCGGCATCTCTCCCTGGTTGAAATATGAAGCCGATGGCGGCCCCGGCATGAAGGAGATCATGGCCTTGCTGGGCGGCG
CTATCGATCCGGTGGCCGCGCGTCGGCATTTCTTCAAGGCGCAGCTGCTGTTCTGGATGCTGTGGGCCACCGATGGTCAT
GCCAAGAATTTCTCGCTGTTCCTCAAGGCGGGGGGGCGCTACGAACCCACGCCCCTGTATGACGTGCTGTCGGTGTTTCC
GCTCATTGGCGAAGGGCCGGGCAAACTCTCACCCCATCGCGCCGCCATGGCCATGGCAGTACGCGCCAAGAATGCCCATC
GCAAGATGAAGGACATCCTGCCCCGACACTGGATGGCGCTGGGTAGTCATTTCGGTATCGTCGCCGAGAATGGCGACGGC
CCCCTTGCCATCCTGGAGGAACTGGCCGAGCAGACGGAGCAGGTCATTGCCAAGGTGCAAGCCGATCTGCCCCCAGGCTT
CCCGTCAGAGCTGGCAGCCTCCATCCTGGATGGCCTGCGTCGTTCGGCAAGCAGCCTCCTGTCATTCGTTCAAACTGCGT
GA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9886.26 Da        Isoelectric Point: 6.3161

>AT57986 WP_013232456.1 NZ_CP013136:430503-430772 [Herbaspirillum seropedicae]
MSEFPVRTGRQLPELLQAYRKQSGLTQSEVARRLGVTQQNLSSLERNADKVSAERLIELLNILGVELVLRKIEAAPSDAL
ASPSDTPQW

Download         Length: 270 bp

>AT57986 NZ_CP013136:430503-430772 [Herbaspirillum seropedicae]
ATGAGCGAATTTCCCGTCCGCACCGGCCGCCAGCTACCTGAGCTGTTGCAGGCCTATCGCAAGCAGTCTGGCCTGACCCA
AAGCGAGGTCGCGCGCCGCCTGGGCGTGACCCAGCAGAACCTGTCCTCGTTGGAGCGCAATGCCGACAAGGTGAGCGCCG
AGCGCCTCATCGAGCTGCTCAATATCCTTGGCGTCGAGCTGGTGTTGCGCAAGATCGAAGCGGCCCCCTCCGACGCTCTT
GCTTCCCCCTCGGATACGCCCCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References