57973

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849817..850294 Replicon chromosome
Accession NZ_CP013132
Organism Staphylococcus aureus strain FORC_026

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC26_RS04295 Protein ID WP_000052076.1
Coordinates 849817..850005 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC26_RS04300 Protein ID WP_001059690.1
Coordinates 850034..850294 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC26_RS04265 845808..846328 + 521 Protein_771 hypothetical protein -
FORC26_RS04270 846669..847355 + 687 WP_001793574.1 thermonuclease family protein -
FORC26_RS04275 847712..847912 + 201 WP_001059082.1 cold-shock protein -
FORC26_RS04280 848408..848626 - 219 WP_000005886.1 hypothetical protein -
FORC26_RS04285 848688..848972 - 285 WP_001004401.1 hypothetical protein -
FORC26_RS04290 849060..849629 - 570 WP_001106654.1 hypothetical protein -
FORC26_RS04295 849817..850005 - 189 WP_000052076.1 hypothetical protein Toxin
FORC26_RS04300 850034..850294 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC26_RS04305 850634..850837 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC26_RS04310 850834..851070 - 237 WP_000368687.1 hypothetical protein -
FORC26_RS04315 851294..851875 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
FORC26_RS04320 851924..852541 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
FORC26_RS04325 852696..853190 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC26_RS04330 853589..854011 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
FORC26_RS04335 854159..854875 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T57973 WP_000052076.1 NZ_CP013132:c850005-849817 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T57973 NZ_CP013132:c850005-849817 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT57973 WP_001059690.1 NZ_CP013132:c850294-850034 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT57973 NZ_CP013132:c850294-850034 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References