Detailed information of TA system TA057967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1904363..1905003
• Replicon: chromosome
• Accession: NZ_CP013126
• Organism: Acidipropionibacterium acidipropionici strain CGMCC 1.2230

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K7RZN5
• Locus tag: ASQ49_RS08390
• Protein ID: WP_015071400.1
• Coordinates: 1904363..1904755 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K7S7C8
• Locus tag: ASQ49_RS08395
• Protein ID: WP_015071399.1
• Coordinates: 1904752..1905003 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASQ49_RS08370	1900600..1900890	-	291	WP_148279567.1	metal-sensitive transcriptional regulator	-
ASQ49_RS08375	1901042..1901743	+	702	WP_081685359.1	DUF3151 family protein	-
ASQ49_RS08380	1901804..1902670	+	867	WP_036936754.1	GNAT family N-acetyltransferase	-
ASQ49_RS08385	1902875..1904161	+	1287	WP_015071401.1	adenylosuccinate synthase	-
ASQ49_RS08390	1904363..1904755	-	393	WP_015071400.1	type II toxin-antitoxin system VapC family toxin	Toxin
ASQ49_RS08395	1904752..1905003	-	252	WP_015071399.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
ASQ49_RS08400	1905218..1906537	+	1320	WP_028700705.1	phosphoribosylamine--glycine ligase	-
ASQ49_RS08405	1906599..1908032	+	1434	WP_028700704.1	adenylosuccinate lyase	-
ASQ49_RS08410	1908135..1909067	-	933	WP_028700703.1	hydrogen peroxide-inducible genes activator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13574.31 Da
• Isoelectric Point: 3.9588

>T57967 WP_015071400.1 NZ_CP013126:c1904755-1904363 [Acidipropionibacterium acidipropionici]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAA
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDDFPQTDIVVADR

Nucleotide

• Length: 393 bp

>T57967 NZ_CP013126:c1904755-1904363 [Acidipropionibacterium acidipropionici]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGCT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGACTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.56 Da
• Isoelectric Point: 6.0829

>AT57967 WP_015071399.1 NZ_CP013126:c1905003-1904752 [Acidipropionibacterium acidipropionici]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Nucleotide

• Length: 252 bp

>AT57967 NZ_CP013126:c1905003-1904752 [Acidipropionibacterium acidipropionici]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Structures

Toxin

• AlphaFold DB: K7RZN5

Antitoxin

• AlphaFold DB: K7S7C8