57966

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1296816..1297377 Replicon chromosome
Accession NZ_CP013126
Organism Acidipropionibacterium acidipropionici strain CGMCC 1.2230

Toxin (Protein)


Gene name mazF Uniprot ID A0A806VT27
Locus tag ASQ49_RS05685 Protein ID WP_028700435.1
Coordinates 1297030..1297377 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID K7S105
Locus tag ASQ49_RS05680 Protein ID WP_015071955.1
Coordinates 1296816..1297043 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASQ49_RS05660 1291840..1293825 + 1986 WP_198027851.1 nitrite reductase large subunit NirB -
ASQ49_RS05665 1293852..1294256 + 405 WP_015071959.1 nitrite reductase small subunit NirD -
ASQ49_RS05670 1294350..1296491 - 2142 WP_028700434.1 NAD(+) synthase -
ASQ49_RS05675 1296469..1296660 - 192 WP_036936157.1 hypothetical protein -
ASQ49_RS05680 1296816..1297043 + 228 WP_015071955.1 ribbon-helix-helix domain-containing protein Antitoxin
ASQ49_RS05685 1297030..1297377 + 348 WP_028700435.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ASQ49_RS05690 1297530..1298489 - 960 WP_015071953.1 PfkB domain-containing protein -
ASQ49_RS05695 1298656..1300203 + 1548 WP_051281579.1 glycoside hydrolase family 32 protein -
ASQ49_RS05700 1300733..1301110 + 378 WP_076692651.1 L,D-transpeptidase -
ASQ49_RS17680 1301215..1301766 - 552 WP_015071949.1 zinc-binding dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-35)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12562.56 Da        Isoelectric Point: 11.4911

>T57966 WP_028700435.1 NZ_CP013126:1297030-1297377 [Acidipropionibacterium acidipropionici]
MIRGEVRLVDLDPARPGEVNKRRPAVLVSNDTANRTAARLGRGVVTVVPVTSNVTRVFPFQILLQADETGLRRDSKAQAE
QVRSVSVERIGPVLGMVPADLMSRIDDALRIHLGL

Download         Length: 348 bp

>T57966 NZ_CP013126:1297030-1297377 [Acidipropionibacterium acidipropionici]
ATGATCCGCGGTGAGGTCCGGCTGGTCGATCTGGATCCGGCGCGCCCCGGCGAGGTGAACAAGCGACGTCCCGCCGTCCT
CGTGAGCAATGACACGGCGAACCGGACGGCCGCACGGCTGGGGCGGGGAGTGGTGACGGTGGTGCCGGTCACCAGCAACG
TCACCCGGGTCTTCCCCTTCCAAATCCTGCTTCAGGCGGACGAGACGGGGCTGCGGCGCGATTCCAAGGCCCAGGCCGAG
CAGGTCCGCTCGGTGTCGGTGGAACGGATCGGCCCGGTGCTCGGGATGGTGCCGGCTGATCTCATGAGCCGCATCGATGA
CGCGCTGAGAATCCACCTGGGGCTGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8161.01 Da        Isoelectric Point: 4.0941

>AT57966 WP_015071955.1 NZ_CP013126:1296816-1297043 [Acidipropionibacterium acidipropionici]
MKLSVSLSKEQVETIDRYIRATGMRSRSAVIQKAIGMLGAPELEGDYAAAWDEWESGDAEAWESTAADGLGDDPR

Download         Length: 228 bp

>AT57966 NZ_CP013126:1296816-1297043 [Acidipropionibacterium acidipropionici]
ATGAAACTCAGTGTCAGCCTGTCCAAGGAGCAGGTGGAGACCATCGACCGGTACATCCGTGCCACCGGGATGAGGTCGAG
GTCCGCGGTGATCCAGAAGGCGATCGGCATGCTCGGCGCCCCGGAGCTCGAGGGGGACTACGCCGCCGCCTGGGACGAGT
GGGAGTCCGGGGACGCCGAGGCCTGGGAGTCGACGGCCGCCGATGGGCTCGGCGATGATCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VT27

Antitoxin

Source ID Structure
AlphaFold DB K7S105

References