Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 1111802..1112484 | Replicon | chromosome |
| Accession | NZ_CP013126 | ||
| Organism | Acidipropionibacterium acidipropionici strain CGMCC 1.2230 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | ASQ49_RS04940 | Protein ID | WP_051281999.1 |
| Coordinates | 1112065..1112484 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | K7SF30 |
| Locus tag | ASQ49_RS04935 | Protein ID | WP_015068797.1 |
| Coordinates | 1111802..1112065 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASQ49_RS04905 | 1107222..1107656 | + | 435 | WP_028701403.1 | hypothetical protein | - |
| ASQ49_RS17370 | 1107653..1107805 | + | 153 | WP_154662074.1 | hypothetical protein | - |
| ASQ49_RS04915 | 1108529..1109326 | + | 798 | WP_157756374.1 | MFS transporter | - |
| ASQ49_RS04920 | 1109390..1110682 | - | 1293 | WP_028701406.1 | ArsB/NhaD family transporter | - |
| ASQ49_RS04925 | 1110735..1111184 | - | 450 | WP_015068799.1 | CBS domain-containing protein | - |
| ASQ49_RS04930 | 1111414..1111680 | + | 267 | WP_015068798.1 | hypothetical protein | - |
| ASQ49_RS04935 | 1111802..1112065 | + | 264 | WP_015068797.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| ASQ49_RS04940 | 1112065..1112484 | + | 420 | WP_051281999.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| ASQ49_RS04945 | 1112646..1112957 | - | 312 | WP_081685418.1 | helix-turn-helix domain-containing protein | - |
| ASQ49_RS04950 | 1112957..1113324 | - | 368 | Protein_989 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ASQ49_RS04960 | 1113712..1114629 | + | 918 | WP_081685417.1 | SDR family oxidoreductase | - |
| ASQ49_RS04965 | 1114791..1115108 | + | 318 | WP_198027931.1 | PadR family transcriptional regulator | - |
| ASQ49_RS04970 | 1115108..1115515 | + | 408 | WP_126133026.1 | DUF1048 domain-containing protein | - |
| ASQ49_RS04975 | 1115512..1116315 | + | 804 | WP_028701410.1 | ATP-binding cassette domain-containing protein | - |
| ASQ49_RS04980 | 1116312..1117073 | + | 762 | WP_015068790.1 | ABC transporter permease | - |
| ASQ49_RS04985 | 1117090..1117473 | - | 384 | WP_028701411.1 | D-ribose pyranase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15091.37 Da Isoelectric Point: 4.9147
>T57965 WP_051281999.1 NZ_CP013126:1112065-1112484 [Acidipropionibacterium acidipropionici]
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHSLGLEVVAPGTPRNPQPNII
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHSLGLEVVAPGTPRNPQPNII
Download Length: 420 bp
>T57965 NZ_CP013126:1112065-1112484 [Acidipropionibacterium acidipropionici]
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTTGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACTGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACAGCCTGGGGCTGGAGGTCGTCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATCTGA
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTTGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACTGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACAGCCTGGGGCTGGAGGTCGTCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATCTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9390.67 Da Isoelectric Point: 10.3568
>AT57965 WP_015068797.1 NZ_CP013126:1111802-1112065 [Acidipropionibacterium acidipropionici]
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
Download Length: 264 bp
>AT57965 NZ_CP013126:1111802-1112065 [Acidipropionibacterium acidipropionici]
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGTCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGTCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|