Detailed information of TA system TA057960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PfiT-PfiA/ParE(toxin)
• Location: 1594571..1595170
• Replicon: chromosome
• Accession: NZ_CP013124
• Organism: Pseudomonas mendocina S5.2

Toxin (Protein)

• Gene name: PfiT
• Uniprot ID: -
• Locus tag: DW68_RS07525
• Protein ID: WP_017362622.1
• Coordinates: 1594832..1595170 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: PfiA
• Uniprot ID: -
• Locus tag: DW68_RS07520
• Protein ID: WP_017362623.1
• Coordinates: 1594571..1594819 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DW68_RS07495	1589662..1590414	+	753	WP_017362628.1	phage Gp37/Gp68 family protein	-
DW68_RS07500	1590395..1591228	-	834	WP_196770182.1	three-Cys-motif partner protein TcmP	-
DW68_RS07505	1591438..1592724	+	1287	WP_017362626.1	three-Cys-motif partner protein TcmP	-
DW68_RS07510	1592805..1592999	-	195	WP_017362625.1	hypothetical protein	-
DW68_RS07515	1593355..1593987	-	633	WP_026042090.1	hypothetical protein	-
DW68_RS07520	1594571..1594819	+	249	WP_017362623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DW68_RS07525	1594832..1595170	+	339	WP_017362622.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DW68_RS07530	1595493..1595819	+	327	WP_026042089.1	hypothetical protein	-
DW68_RS07535	1595824..1596858	-	1035	WP_017362620.1	GGDEF domain-containing protein	-
DW68_RS07540	1597119..1597529	-	411	WP_017362619.1	GNAT family N-acetyltransferase	-
DW68_RS07545	1597640..1597969	-	330	WP_013716569.1	DUF2025 family protein	-
DW68_RS07550	1598067..1598468	-	402	WP_013716568.1	NUDIX domain-containing protein	-
DW68_RS07555	1598510..1599211	-	702	WP_017362618.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1580918..1595170	14252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12489.02 Da
• Isoelectric Point: 4.3516

>T57960 WP_017362622.1 NZ_CP013124:1594832-1595170 [Pseudomonas mendocina S5.2]
MTTLDVRFTDSAYQSIEDQVHHLAAYQGTEAALASVDSLVDVITDKLKSAPKGYPVSQQASELGVTQYRELNTDGYRVLY
EVYDSDIAVELILRQKQSVEQALIRYCLLSAV

Nucleotide

• Length: 339 bp

>T57960 NZ_CP013124:1594832-1595170 [Pseudomonas mendocina S5.2]
ATGACAACACTTGACGTACGCTTCACTGATTCCGCTTACCAGAGCATCGAAGACCAGGTTCACCATCTGGCCGCTTACCA
AGGCACCGAAGCCGCCCTTGCGAGTGTCGACTCGTTGGTAGATGTCATCACGGACAAGCTTAAGTCCGCACCCAAGGGGT
ACCCAGTCAGCCAGCAGGCAAGTGAACTGGGAGTCACCCAATATCGCGAACTCAATACTGACGGCTATCGAGTCCTCTAT
GAGGTGTACGATTCCGATATTGCGGTTGAGTTGATTCTGAGGCAGAAGCAGAGCGTCGAGCAGGCCCTGATCCGCTACTG
CTTGCTGAGTGCTGTCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9303.65 Da
• Isoelectric Point: 8.9236

>AT57960 WP_017362623.1 NZ_CP013124:1594571-1594819 [Pseudomonas mendocina S5.2]
MRVETISYLKRHAADLDLDEPMIVTQNGVPAYVVESYADRKRRDEAIALVKLLAIGSREYAQGKHCSADELKARLARRFA
QN

Nucleotide

• Length: 249 bp

>AT57960 NZ_CP013124:1594571-1594819 [Pseudomonas mendocina S5.2]
ATGAGGGTTGAAACGATTAGCTATTTGAAAAGACACGCTGCCGATCTGGATCTCGATGAGCCCATGATCGTCACGCAGAA
CGGTGTACCAGCCTATGTAGTGGAGTCTTACGCCGACCGTAAGCGCCGCGACGAAGCTATCGCCCTGGTGAAGCTACTTG
CAATCGGTTCGCGCGAGTACGCTCAAGGTAAGCACTGCTCTGCTGACGAGCTGAAGGCCCGCCTGGCCAGGAGGTTTGCC
CAAAATTAA