Detailed information of TA system TA057959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1403204..1404636
• Replicon: chromosome
• Accession: NZ_CP013124
• Organism: Pseudomonas mendocina S5.2

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A550FMU2
• Locus tag: DW68_RS06590
• Protein ID: WP_013716747.1
• Coordinates: 1403204..1403773 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: DW68_RS06595
• Protein ID: WP_017362765.1
• Coordinates: 1403779..1404636 (+)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DW68_RS06580	1398648..1399457	+	810	WP_026042105.1	MerR family transcriptional regulator	-
DW68_RS06585	1399513..1403001	-	3489	WP_013716748.1	hybrid sensor histidine kinase/response regulator	-
DW68_RS06590	1403204..1403773	+	570	WP_013716747.1	GNAT family N-acetyltransferase	Toxin
DW68_RS06595	1403779..1404636	+	858	WP_017362765.1	AraC family transcriptional regulator	Antitoxin
DW68_RS06600	1404699..1406036	-	1338	WP_013716745.1	peptidase	-
DW68_RS06605	1406226..1406798	+	573	WP_013716744.1	LemA family protein	-
DW68_RS06610	1406809..1407714	+	906	WP_017362764.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (17-145)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21511.68 Da
• Isoelectric Point: 7.2799

>T57959 WP_013716747.1 NZ_CP013124:1403204-1403773 [Pseudomonas mendocina S5.2]
MFKPQLVTLQRGALRLEPLSDADIPALVALAEANREELLYMSGTQRLDWYRSALADLREQRALPFVIRLGDELVGTTRFA
DFMNTLPACEIGWTWLDRNQHGSGLNTTIKYLMLRHAFDNWGMVRVQLKTAASNQRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSITDLEWPALREAMEAGFVA

Nucleotide

• Length: 570 bp

>T57959 NZ_CP013124:1403204-1403773 [Pseudomonas mendocina S5.2]
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTTTGCGCCTGGAACCGCTCTCCGATGCGGATATCCCGGCGTT
GGTAGCGTTGGCCGAGGCCAATCGCGAAGAGCTGCTGTACATGAGCGGTACCCAGCGGCTGGACTGGTACCGCAGCGCCC
TGGCCGATCTGCGCGAGCAGCGCGCACTGCCGTTCGTCATTCGCCTGGGTGACGAGTTGGTGGGCACCACCCGTTTCGCC
GATTTCATGAACACCCTGCCGGCCTGCGAAATCGGCTGGACCTGGCTCGACCGCAATCAGCATGGCAGCGGCCTGAACAC
CACCATCAAGTACCTGATGCTCAGGCACGCCTTCGACAACTGGGGCATGGTCCGTGTGCAGCTGAAAACCGCTGCCAGCA
ACCAGCGCTCGCAACGTGCCATCGAGAAACTGGGTGCTGTCCGTGAGGGATTGCTGCGCAACCATCGCCGGCTGGCCGAT
GGCCGTCTCGACGATACCGTGCTGTACAGCATCACCGATCTGGAGTGGCCGGCGCTGCGAGAGGCGATGGAGGCGGGCTT
CGTCGCCTGA

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31788.23 Da
• Isoelectric Point: 9.7404

>AT57959 WP_017362765.1 NZ_CP013124:1403779-1404636 [Pseudomonas mendocina S5.2]
MQAREQTRFWQASALSGVELLQARYLEQRFAPHVHEGFVFTVIEHGAQRFHHRGSDHLAPQGSMVLINPDEVHTGSKAHE
DGWRYRGFYPGNDQVLGALQELGLAKTGMPSFSFSVLHDPQLHSAFLQLHRLLDGGAEALQQQLAWREAILLLFQRHARL
AEPAAPGREPWAVACAKQMLAERLIEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLKTGCTAVT
VATQLGFADQSHLSRQFKQVYGVSPGEYRSAVARIVAKGAHPGER

Nucleotide

• Length: 858 bp

>AT57959 NZ_CP013124:1403779-1404636 [Pseudomonas mendocina S5.2]
ATGCAAGCCCGCGAGCAGACCCGCTTCTGGCAGGCATCCGCGTTGAGCGGAGTCGAGCTGTTGCAGGCTCGCTACCTCGA
ACAACGCTTCGCGCCTCATGTCCATGAGGGCTTCGTCTTCACCGTGATCGAGCACGGTGCGCAGCGTTTTCACCACCGTG
GCAGCGACCACCTGGCGCCACAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGTTCCAAGGCGCACGAG
GATGGCTGGCGTTATCGCGGCTTCTATCCGGGTAATGATCAGGTGCTGGGGGCGCTGCAGGAACTGGGCCTGGCCAAGAC
GGGCATGCCGTCGTTTTCCTTCAGCGTGCTGCATGATCCGCAGTTGCACAGCGCCTTCCTGCAACTGCATCGCCTGCTCG
ACGGCGGCGCCGAAGCACTGCAGCAGCAACTGGCCTGGCGCGAGGCGATTCTGCTGCTGTTCCAGCGTCACGCCAGGCTT
GCCGAGCCAGCTGCGCCCGGACGTGAGCCCTGGGCCGTAGCCTGTGCCAAGCAGATGCTCGCCGAGCGCCTGATCGAGCC
GCCGTCCCTGGAAGAGCTGGCGGCTGCGGTCAACCTTTCTCCCTTCCACTTCGCCCGGGTGTTTCGCCGTGCGACCGGTC
TGCCGCCGCACGCCTGGCTCAAACAGCGTCGTCTGGAACAGGCGCGGGCGTTGCTCAAGACCGGCTGCACGGCGGTCACC
GTGGCGACGCAGCTGGGTTTTGCCGACCAGAGCCACCTGTCACGACAGTTCAAGCAGGTCTATGGCGTCAGCCCTGGCGA
ATATCGCAGCGCCGTGGCACGGATTGTGGCTAAGGGCGCGCATCCTGGCGAACGGTGA

Structures

Toxin

• AlphaFold DB: A0A550FMU2