Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2361827..2362341 Replicon chromosome
Accession NZ_CP013121
Organism Fusobacterium nucleatum subsp. polymorphum strain ChDC F306

Toxin (Protein)


Gene name relB Uniprot ID A0A0S2ZR73
Locus tag RO02_RS11485 Protein ID WP_060496756.1
Coordinates 2362084..2362341 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag RO02_RS11480 Protein ID WP_005919458.1
Coordinates 2361827..2362084 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RO02_RS11460 2356960..2359053 + 2094 WP_060496754.1 outer membrane protein assembly factor -
RO02_RS11465 2359093..2359566 + 474 WP_005894577.1 OmpH family outer membrane protein -
RO02_RS11470 2359592..2360590 + 999 WP_023037958.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
RO02_RS11475 2360634..2361707 + 1074 WP_060496755.1 glycerophosphodiester phosphodiesterase -
RO02_RS11480 2361827..2362084 + 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RO02_RS11485 2362084..2362341 + 258 WP_060496756.1 Txe/YoeB family addiction module toxin Toxin
RO02_RS11490 2362458..2363534 + 1077 WP_023037955.1 DHH family phosphoesterase -
RO02_RS11495 2363766..2364503 + 738 WP_187102957.1 tRNA pseudouridine(38-40) synthase TruA -
RO02_RS11500 2364626..2365483 + 858 WP_005901425.1 toxin-antitoxin system YwqK family antitoxin -
RO02_RS11505 2365752..2366384 + 633 WP_032834175.1 DUF1871 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10160.65 Da        Isoelectric Point: 8.8765

>T57958 WP_060496756.1 NZ_CP013121:2362084-2362341 [Fusobacterium nucleatum subsp. polymorphum]
MLLTWTDFAWEQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Download         Length: 258 bp

>T57958 NZ_CP013121:2362084-2362341 [Fusobacterium nucleatum subsp. polymorphum]
ATGTTATTAACTTGGACCGATTTTGCATGGGAACAATATGAAGAGTTACAAGAAAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAAGGAATAGGTAAACCAGAGCCTTTACAACATGAGTTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAATCAAATAACAATAGTTGCTTGT
GCGAATCATTATAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT57958 WP_005919458.1 NZ_CP013121:2361827-2362084 [Fusobacterium nucleatum subsp. polymorphum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT57958 NZ_CP013121:2361827-2362084 [Fusobacterium nucleatum subsp. polymorphum]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAAGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATACAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2ZR73

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References