Detailed information of TA system TA057957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2091108..2091501
• Replicon: chromosome
• Accession: NZ_CP013121
• Organism: Fusobacterium nucleatum subsp. polymorphum strain ChDC F306

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: RO02_RS13150
• Protein ID: WP_141757152.1
• Coordinates: 2091373..2091501 (+)
• Length: 43 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0S2ZWS3
• Locus tag: RO02_RS10195
• Protein ID: WP_060496642.1
• Coordinates: 2091108..2091371 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RO02_RS10175	2087562..2088458	+	897	WP_032890429.1	quinolinate synthase NadA	-
RO02_RS10180	2088460..2089752	+	1293	WP_060496640.1	L-aspartate oxidase	-
RO02_RS10185	2089730..2090590	+	861	WP_060496641.1	carboxylating nicotinate-nucleotide diphosphorylase	-
RO02_RS10190	2090583..2091092	+	510	WP_032890435.1	transcription repressor NadR	-
RO02_RS10195	2091108..2091371	+	264	WP_060496642.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
RO02_RS13150	2091373..2091501	+	129	WP_141757152.1	type II toxin-antitoxin system YafQ family toxin	Toxin
RO02_RS10205	2091503..2092267	+	765	WP_008694117.1	class I SAM-dependent methyltransferase	-
RO02_RS10210	2092626..2093132	-	507	WP_060496643.1	AAA family ATPase	-
RO02_RS10215	2093177..2093680	-	504	WP_060496644.1	YfbM family protein	-
RO02_RS10220	2093825..2094514	+	690	WP_060496645.1	DUF554 domain-containing protein	-
RO02_RS10225	2094511..2095062	-	552	WP_060496646.1	hypothetical protein	-
RO02_RS10230	2095163..2096256	+	1094	Protein_2029	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2095163..2096068	905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-37)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-86)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4990.10 Da
• Isoelectric Point: 10.8454

>T57957 WP_141757152.1 NZ_CP013121:2091373-2091501 [Fusobacterium nucleatum subsp. polymorphum]
MYEIKTTTKFEKDLKLMKKRGYNLKLLKEVINMLSKGAKSRL

Nucleotide

• Length: 129 bp

>T57957 NZ_CP013121:2091373-2091501 [Fusobacterium nucleatum subsp. polymorphum]
ATGTATGAAATTAAGACCACTACTAAATTTGAAAAAGACTTAAAATTAATGAAAAAAAGAGGATATAATTTAAAATTATT
AAAAGAGGTAATTAATATGTTATCTAAAGGAGCTAAAAGCAGATTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9835.46 Da
• Isoelectric Point: 5.1615

>AT57957 WP_060496642.1 NZ_CP013121:2091108-2091371 [Fusobacterium nucleatum subsp. polymorphum]
MAVINIRVNDEVKKEAETIFKSLGLNMSVAMNLFLKKCINENGMPFDLKIPNKKTIEAMEGTNKILNGDIERKSYKNADE
LFEDLGV

Nucleotide

• Length: 264 bp

>AT57957 NZ_CP013121:2091108-2091371 [Fusobacterium nucleatum subsp. polymorphum]
ATGGCTGTTATAAATATTCGTGTTAATGATGAAGTAAAAAAAGAAGCTGAAACTATTTTTAAATCTTTGGGACTTAATAT
GTCAGTTGCAATGAATTTATTTCTAAAAAAATGTATAAATGAAAATGGGATGCCATTTGATTTAAAAATTCCAAATAAAA
AAACAATAGAAGCAATGGAAGGAACTAACAAAATATTAAATGGAGATATAGAAAGAAAGTCATATAAAAATGCTGATGAG
TTATTTGAAGATTTAGGTGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S2ZWS3