Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 3608528..3609038 Replicon chromosome
Accession NZ_CP013119
Organism Alcaligenes faecalis strain ZD02

Toxin (Protein)


Gene name relB Uniprot ID U1YHF7
Locus tag UZ73_RS16270 Protein ID WP_009459444.1
Coordinates 3608528..3608791 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2U2BGR2
Locus tag UZ73_RS16275 Protein ID WP_045931650.1
Coordinates 3608784..3609038 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UZ73_RS16240 3603533..3604051 - 519 WP_042488913.1 DedA family protein -
UZ73_RS16245 3604088..3604558 - 471 WP_045931654.1 GNAT family N-acetyltransferase -
UZ73_RS16250 3604555..3604956 - 402 WP_045931653.1 hypothetical protein -
UZ73_RS16255 3605293..3606051 - 759 WP_045931652.1 M48 family metallopeptidase -
UZ73_RS16260 3606227..3607366 - 1140 WP_045931651.1 MFS transporter -
UZ73_RS16270 3608528..3608791 - 264 WP_009459444.1 Txe/YoeB family addiction module toxin Toxin
UZ73_RS16275 3608784..3609038 - 255 WP_045931650.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
UZ73_RS16280 3609229..3609498 + 270 WP_045931649.1 hypothetical protein -
UZ73_RS19445 3609536..3610225 - 690 WP_086061075.1 LexA family transcriptional regulator -
UZ73_RS19650 3610308..3610499 + 192 WP_094196318.1 hypothetical protein -
UZ73_RS16290 3610766..3611557 + 792 WP_052695868.1 hypothetical protein -
UZ73_RS16295 3611541..3612248 + 708 WP_052695867.1 hypothetical protein -
UZ73_RS16300 3612292..3612579 + 288 WP_189319714.1 DUF1064 domain-containing protein -
UZ73_RS16305 3612593..3612973 + 381 WP_045931647.1 hypothetical protein -
UZ73_RS16310 3612970..3613218 + 249 WP_009459904.1 hypothetical protein -
UZ73_RS16315 3613393..3613812 + 420 WP_045931646.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10382.88 Da        Isoelectric Point: 9.0343

>T57954 WP_009459444.1 NZ_CP013119:c3608791-3608528 [Alcaligenes faecalis]
MTDRLLCWTDAAWIDYVYWQGQDRKTLKRINRLIEEVRRAPFDGIGKPEALKENLSGFWSRRIDDTNRLVYAVDKASITI
ISCRYHY

Download         Length: 264 bp

>T57954 NZ_CP013119:c3608791-3608528 [Alcaligenes faecalis]
ATGACTGACCGACTTCTGTGCTGGACCGACGCTGCCTGGATTGACTATGTGTACTGGCAAGGTCAGGACCGCAAGACCTT
GAAGCGTATCAACAGACTGATAGAAGAAGTACGACGTGCGCCGTTCGATGGCATAGGCAAGCCTGAAGCGCTCAAAGAGA
ATCTGTCCGGTTTCTGGTCAAGACGCATTGATGACACGAATCGCCTGGTCTATGCCGTAGACAAGGCAAGCATCACGATT
ATTTCTTGCCGTTATCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9413.59 Da        Isoelectric Point: 4.7778

>AT57954 WP_045931650.1 NZ_CP013119:c3609038-3608784 [Alcaligenes faecalis]
MKIISFSEARNSLKAVLDGVVDDANTTIITRRDAEDAVVMSLDYYNSLMETVHLLRSPANAEHLSRSIEQYRAGKAMPRE
LSDD

Download         Length: 255 bp

>AT57954 NZ_CP013119:c3609038-3608784 [Alcaligenes faecalis]
ATGAAAATCATCTCGTTTTCAGAAGCGCGCAACAGTTTGAAAGCGGTACTGGATGGCGTAGTGGATGACGCCAACACCAC
CATCATTACGCGTCGTGACGCCGAAGATGCGGTGGTCATGTCACTCGATTACTACAACAGCCTGATGGAAACCGTGCACC
TGCTGCGCTCCCCCGCCAATGCGGAACACCTGAGCCGTTCTATCGAACAGTATCGTGCCGGCAAAGCCATGCCACGCGAG
CTGAGCGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U1YHF7

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2BGR2

References