Detailed information of TA system TA057951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1855896..1856416
• Replicon: chromosome
• Accession: NZ_CP013114
• Organism: Staphylococcus equorum strain KS1039

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: SE1039_RS09030
• Protein ID: WP_040762585.1
• Coordinates: 1855896..1856108 (-)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: J9GWP4
• Locus tag: SE1039_RS09035
• Protein ID: WP_002507096.1
• Coordinates: 1856123..1856416 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SE1039_RS09015	1851471..1852826	-	1356	WP_056935789.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
SE1039_RS09020	1852839..1853909	-	1071	WP_002507100.1	D-alanine--D-alanine ligase	-
SE1039_RS09025	1854184..1855386	+	1203	WP_056935790.1	rod shape-determining protein RodA	-
SE1039_RS13790	1855542..1855682	-	141	WP_002507098.1	hypothetical protein	-
SE1039_RS09030	1855896..1856108	-	213	WP_040762585.1	heavy-metal-associated domain-containing protein	Toxin
SE1039_RS09035	1856123..1856416	-	294	WP_002507096.1	copper-sensing transcriptional repressor CsoR	Antitoxin
SE1039_RS09040	1856560..1858044	+	1485	WP_056935791.1	cardiolipin synthase	-
SE1039_RS09045	1858172..1858822	+	651	WP_056935792.1	HD domain-containing protein	-
SE1039_RS09050	1858893..1859762	-	870	WP_056935793.1	membrane protein insertase YidC	-
SE1039_RS09055	1859850..1860488	-	639	WP_021339941.1	thiamine phosphate synthase	-
SE1039_RS09060	1860488..1861279	-	792	WP_056936209.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (18-67)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8130.16 Da
• Isoelectric Point: 4.5086

>T57951 WP_040762585.1 NZ_CP013114:c1856108-1855896 [Staphylococcus equorum]
VITKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Nucleotide

• Length: 213 bp

>T57951 NZ_CP013114:c1856108-1855896 [Staphylococcus equorum]
GTGATAACAAAAGTTATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCAGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.87 Da
• Isoelectric Point: 6.4791

>AT57951 WP_002507096.1 NZ_CP013114:c1856416-1856123 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT57951 NZ_CP013114:c1856416-1856123 [Staphylococcus equorum]
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGATGTTCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG

Structures

Antitoxin

• AlphaFold DB: J9GWP4