Detailed information of TA system TA057950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1844414..1844943
• Replicon: chromosome
• Accession: NZ_CP013114
• Organism: Staphylococcus equorum strain KS1039

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K7S376
• Locus tag: SE1039_RS08975
• Protein ID: WP_002511418.1
• Coordinates: 1844414..1844776 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: J9GY23
• Locus tag: SE1039_RS08980
• Protein ID: WP_002507108.1
• Coordinates: 1844773..1844943 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SE1039_RS08955	1841413..1842183	-	771	WP_002507114.1	RNA polymerase sigma factor SigB	-
SE1039_RS08960	1842158..1842640	-	483	WP_002507113.1	anti-sigma B factor RsbW	-
SE1039_RS08965	1842642..1842968	-	327	WP_002511417.1	anti-sigma factor antagonist	-
SE1039_RS08970	1843048..1844049	-	1002	WP_002507111.1	PP2C family protein-serine/threonine phosphatase	-
SE1039_RS08975	1844414..1844776	-	363	WP_002511418.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SE1039_RS08980	1844773..1844943	-	171	WP_002507108.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SE1039_RS08985	1845031..1846179	-	1149	WP_002507107.1	alanine racemase	-
SE1039_RS08990	1846303..1846653	-	351	WP_002507106.1	holo-ACP synthase	-
SE1039_RS08995	1846686..1847222	-	537	WP_002507105.1	PH domain-containing protein	-
SE1039_RS09000	1847215..1848720	-	1506	WP_056935788.1	PH domain-containing protein	-
SE1039_RS09005	1848713..1849192	-	480	WP_002507103.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13432.59 Da
• Isoelectric Point: 10.2178

>T57950 WP_002511418.1 NZ_CP013114:c1844776-1844414 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Nucleotide

• Length: 363 bp

>T57950 NZ_CP013114:c1844776-1844414 [Staphylococcus equorum]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
TATCATACAGAATGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCTGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAGCTTGATAAAGATTCTGTAATACTGCTTGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACATACCTTTCTGAAAGTAAAATGAAAGAAGTTAATGTTGCCATAGA
TATAAGCTTAGGATTACATAATGTTAGAAATAGTAAATCATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6305.92 Da
• Isoelectric Point: 4.0121

>AT57950 WP_002507108.1 NZ_CP013114:c1844943-1844773 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Nucleotide

• Length: 171 bp

>AT57950 NZ_CP013114:c1844943-1844773 [Staphylococcus equorum]
ATGGCAAGTTTTAATCAAAGCAGAAACCATAGTATTGAACAACTATTAAAAGAAGGCTATTCACAAATGGCCGATTTAAA
TCTCTCCCTTGCAGCAGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAGTTTACCTCAGCTCTAAGAATA
ACAATGAATGA

Structures

Toxin

• AlphaFold DB: K7S376

Antitoxin

• AlphaFold DB: J9GY23