57945

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4919860..4920468 Replicon chromosome
Accession NZ_CP013113
Organism Pseudomonas aeruginosa strain Paer4_119

Toxin (Protein)


Gene name PfiT Uniprot ID A0A3S4N9Q9
Locus tag AQ622_RS23450 Protein ID WP_031672658.1
Coordinates 4919860..4920207 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag AQ622_RS23455 Protein ID WP_003114155.1
Coordinates 4920217..4920468 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ622_RS23420 4915220..4915492 + 273 WP_003120794.1 cysteine-rich CWC family protein -
AQ622_RS23425 4915492..4916184 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
AQ622_RS23430 4916320..4917363 + 1044 WP_003098363.1 L,D-transpeptidase -
AQ622_RS23435 4917443..4918180 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
AQ622_RS23440 4918631..4919533 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
AQ622_RS23450 4919860..4920207 - 348 WP_031672658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ622_RS23455 4920217..4920468 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AQ622_RS23460 4920682..4921665 - 984 WP_031672657.1 tyrosine-type recombinase/integrase -
AQ622_RS23465 4921665..4922957 - 1293 WP_071659043.1 hypothetical protein -
AQ622_RS23470 4923216..4924478 - 1263 WP_049290957.1 hypothetical protein -
AQ622_RS23475 4924480..4924830 - 351 WP_003159569.1 DUF2523 domain-containing protein -
AQ622_RS23480 4924840..4925448 - 609 WP_003163344.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4919710..4933016 13306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12898.69 Da        Isoelectric Point: 4.5143

>T57945 WP_031672658.1 NZ_CP013113:c4920207-4919860 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGAQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T57945 NZ_CP013113:c4920207-4919860 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGCACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT57945 WP_003114155.1 NZ_CP013113:c4920468-4920217 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT57945 NZ_CP013113:c4920468-4920217 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4N9Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References