Detailed information of TA system TA057942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2718735..2719777
• Replicon: chromosome
• Accession: NZ_CP013113
• Organism: Pseudomonas aeruginosa strain Paer4_119

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: AQ622_RS13155
• Protein ID: WP_003109777.1
• Coordinates: 2719202..2719777 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: I3TV68
• Locus tag: AQ622_RS13150
• Protein ID: WP_003050245.1
• Coordinates: 2718735..2719205 (+)
• Length: 157 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AQ622_RS13115	2714127..2715545	-	1419	WP_020924934.1	TIGR03752 family integrating conjugative element protein	-
AQ622_RS13120	2715535..2716446	-	912	WP_003105643.1	TIGR03749 family integrating conjugative element protein	-
AQ622_RS13125	2716443..2717135	-	693	WP_003105641.1	TIGR03746 family integrating conjugative element protein	-
AQ622_RS13130	2717132..2717530	-	399	WP_003105639.1	TIGR03750 family conjugal transfer protein	-
AQ622_RS13135	2717542..2717901	-	360	WP_003090173.1	TIGR03745 family integrating conjugative element membrane protein	-
AQ622_RS13140	2717918..2718151	-	234	WP_003050225.1	TIGR03758 family integrating conjugative element protein	-
AQ622_RS13145	2718148..2718531	-	384	WP_003120001.1	RAQPRD family integrative conjugative element protein	-
AQ622_RS13150	2718735..2719205	+	471	WP_003050245.1	helix-turn-helix domain-containing protein	Antitoxin
AQ622_RS13155	2719202..2719777	+	576	WP_003109777.1	PIN domain-containing protein	Toxin
AQ622_RS13160	2719795..2720709	+	915	WP_003105629.1	AAA family ATPase	-
AQ622_RS13165	2720706..2721176	+	471	WP_003105626.1	hypothetical protein	-
AQ622_RS13170	2721173..2721673	+	501	WP_003090159.1	hypothetical protein	-
AQ622_RS13175	2721673..2722575	+	903	WP_003105624.1	nucleotidyltransferase domain-containing protein	-
AQ622_RS13180	2722614..2723339	+	726	WP_003050273.1	CBASS effector endonuclease NucC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2668342..2769308	100966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-114)

Antitoxin

• Helix-turn-helix domain, group 17 (85-133)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21644.79 Da
• Isoelectric Point: 5.6172

>T57942 WP_003109777.1 NZ_CP013113:2719202-2719777 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Nucleotide

• Length: 576 bp

>T57942 NZ_CP013113:2719202-2719777 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAGGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin

Protein

• Length: 157 a.a.
• Molecular weight: 17245.62 Da
• Isoelectric Point: 6.3803

>AT57942 WP_003050245.1 NZ_CP013113:2718735-2719205 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Nucleotide

• Length: 471 bp

>AT57942 NZ_CP013113:2718735-2719205 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Structures

Antitoxin

• AlphaFold DB: I3TV68