Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150373..150878 Replicon chromosome
Accession NZ_CP013113
Organism Pseudomonas aeruginosa strain Paer4_119

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag AQ622_RS00705 Protein ID WP_003121619.1
Coordinates 150373..150654 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag AQ622_RS00710 Protein ID WP_003112628.1
Coordinates 150651..150878 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ622_RS00680 145624..146973 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
AQ622_RS00685 147022..147708 + 687 WP_003083762.1 FadR family transcriptional regulator -
AQ622_RS00690 147809..148543 + 735 WP_003117208.1 GntR family transcriptional regulator -
AQ622_RS00695 148747..149133 + 387 WP_014602345.1 aegerolysin family protein -
AQ622_RS00700 149165..150073 - 909 WP_003083769.1 LysR family transcriptional regulator -
AQ622_RS00705 150373..150654 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
AQ622_RS00710 150651..150878 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
AQ622_RS00715 151054..151674 - 621 WP_003101226.1 hypothetical protein -
AQ622_RS00720 151775..152275 + 501 WP_003112629.1 LEA type 2 family protein -
AQ622_RS00725 152348..152689 + 342 WP_003101229.1 alkylphosphonate utilization protein -
AQ622_RS00730 152771..154198 - 1428 WP_003121620.1 GABA permease -
AQ622_RS00735 154367..155860 - 1494 WP_031653061.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T57940 WP_003121619.1 NZ_CP013113:c150654-150373 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T57940 NZ_CP013113:c150654-150373 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT57940 WP_003112628.1 NZ_CP013113:c150878-150651 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT57940 NZ_CP013113:c150878-150651 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References