Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2747209..2748007 Replicon chromosome
Accession NZ_CP013112
Organism Escherichia coli strain YD786

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag ASE18_RS13560 Protein ID WP_057916008.1
Coordinates 2747630..2748007 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4NTN5
Locus tag ASE18_RS13555 Protein ID WP_001605875.1
Coordinates 2747209..2747583 (+) Length 125 a.a.

Genomic Context


ASE18_RS25120ASE18_RS13535ASE18_RS13540ASE18_RS13545ASE18_RS13550ASE18_RS13555ASE18_RS13560ASE18_RS26935ASE18_RS26940ASE18_RS13575ASE18_RS13580ASE18_RS13585ASE18_RS13590ASE18_RS13595
Location: 2744400..2744630 (231 bp)
Type: Others
Protein ID: Protein_2583
Location: 2744958..2745776 (819 bp)
Type: Others
Protein ID: WP_001234393.1
Location: 2745868..2746353 (486 bp)
Type: Others
Protein ID: WP_001536436.1
Location: 2746369..2746845 (477 bp)
Type: Others
Protein ID: WP_057916007.1
Location: 2746914..2747135 (222 bp)
Type: Others
Protein ID: WP_000692303.1
Location: 2747209..2747583 (375 bp)
Type: Antitoxin
Protein ID: WP_001605875.1
Location: 2747630..2748007 (378 bp)
Type: Toxin
Protein ID: WP_057916008.1
Location: 2748004..2748153 (150 bp)
Type: Others
Protein ID: Protein_2590
Location: 2748229..2748426 (198 bp)
Type: Others
Protein ID: WP_023563519.1
Location: 2748511..2749353 (843 bp)
Type: Others
Protein ID: WP_057916009.1
Location: 2749634..2750170 (537 bp)
Type: Others
Protein ID: WP_000942786.1
Location: 2750172..2751350 (1179 bp)
Type: Others
Protein ID: WP_000094970.1
Location: 2751347..2752324 (978 bp)
Type: Others
Protein ID: WP_000633220.1
Location: 2752327..2752530 (204 bp)
Type: Others
Protein ID: Protein_2596
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASE18_RS251202744400..2744630+231Protein_2583autotransporter domain-containing protein-
ASE18_RS135352744958..2745776+819WP_001234393.1DUF945 domain-containing protein-
ASE18_RS135402745868..2746353+486WP_001536436.1antirestriction protein-
ASE18_RS135452746369..2746845+477WP_057916007.1RadC family protein-
ASE18_RS135502746914..2747135+222WP_000692303.1DUF987 domain-containing protein-
ASE18_RS135552747209..2747583+375WP_001605875.1type IV toxin-antitoxin system toxin CbtAAntitoxin
ASE18_RS135602747630..2748007+378WP_057916008.1TA system toxin CbtA family proteinToxin
ASE18_RS269352748004..2748153+150Protein_2590hypothetical protein-
ASE18_RS269402748229..2748426+198WP_023563519.1DUF957 domain-containing protein-
ASE18_RS135752748511..2749353+843WP_057916009.1DUF4942 domain-containing protein-
ASE18_RS135802749634..2750170-537WP_000942786.1GspM family type II secretion system protein YghD-
ASE18_RS135852750172..2751350-1179WP_000094970.1type II secretion system protein GspL-
ASE18_RS135902751347..2752324-978WP_000633220.1type II secretion system minor pseudopilin GspK-
ASE18_RS135952752327..2752530-204Protein_2596type II secretion system protein GspJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14140.14 Da        Isoelectric Point: 7.2652

>T57934 WP_057916008.1 NZ_CP013112:2747630-2748007 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATSLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T57934 NZ_CP013112:2747630-2748007 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCAGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13594.42 Da        Isoelectric Point: 5.4554

>AT57934 WP_001605875.1 NZ_CP013112:2747209-2747583 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT57934 NZ_CP013112:2747209-2747583 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGGCCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1L4NTN5

References