Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 6751..7391 Replicon plasmid A
Accession NZ_CP013108
Organism Sinorhizobium americanum strain CFNEI 73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L3LSG2
Locus tag SAMCFNEI73_RS17855 Protein ID WP_064253140.1
Coordinates 6751..7137 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L3L8D7
Locus tag SAMCFNEI73_RS17860 Protein ID WP_037381694.1
Coordinates 7137..7391 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMCFNEI73_RS17830 1787..2779 + 993 WP_064253152.1 plasmid partitioning protein RepB -
SAMCFNEI73_RS17835 2961..4175 + 1215 WP_064253139.1 replication initiation protein RepC -
SAMCFNEI73_RS17840 4197..4793 - 597 WP_064253153.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
SAMCFNEI73_RS17845 4874..5146 - 273 WP_037381689.1 hypothetical protein -
SAMCFNEI73_RS17850 5353..6528 - 1176 WP_072642841.1 site-specific integrase -
SAMCFNEI73_RS17855 6751..7137 - 387 WP_064253140.1 type II toxin-antitoxin system VapC family toxin Toxin
SAMCFNEI73_RS17860 7137..7391 - 255 WP_037381694.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SAMCFNEI73_RS17865 8060..8638 + 579 WP_064253141.1 hypothetical protein -
SAMCFNEI73_RS17870 8892..10466 + 1575 WP_082912299.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..222756 222756


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13942.77 Da        Isoelectric Point: 4.4049

>T57916 WP_064253140.1 NZ_CP013108:c7137-6751 [Sinorhizobium americanum]
MVIDTSAIVAIAFNEPEAETYEQKVVDAPQRFLSAATLLELTIVIEARLGEAGTAELDLWLHKAGVEIVAVDAEQIAVAR
RAWRSYGKGRHPAGLNYGDCFSYALAKTRSEPLLYKGDDFSLTDIEGA

Download         Length: 387 bp

>T57916 NZ_CP013108:c7137-6751 [Sinorhizobium americanum]
ATGGTCATCGATACGTCCGCGATCGTCGCGATCGCCTTCAATGAGCCGGAAGCGGAAACCTACGAGCAAAAGGTCGTCGA
CGCTCCGCAACGCTTTCTCTCGGCCGCCACGCTCCTGGAACTCACCATTGTCATCGAGGCCCGCCTCGGCGAGGCAGGGA
CCGCAGAGCTCGACCTGTGGCTCCATAAGGCCGGCGTCGAAATCGTAGCCGTCGATGCGGAACAGATCGCGGTGGCAAGG
CGAGCCTGGCGCAGCTATGGCAAGGGCCGACATCCGGCGGGGCTGAACTATGGGGACTGTTTCTCCTATGCGCTGGCCAA
GACACGCAGTGAACCGCTGCTCTATAAGGGCGATGATTTCTCGCTCACAGACATCGAGGGGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9517.89 Da        Isoelectric Point: 6.3783

>AT57916 WP_037381694.1 NZ_CP013108:c7391-7137 [Sinorhizobium americanum]
MALSIKDLETERLAKALAEKTGETITMATRRALEERLRRLANVGNRDVLLEELAASRKRWARLPVLDNRSVDEILGYDEN
GLPN

Download         Length: 255 bp

>AT57916 NZ_CP013108:c7391-7137 [Sinorhizobium americanum]
ATGGCGCTCAGCATTAAAGATCTAGAGACGGAACGCCTCGCAAAGGCACTGGCCGAGAAAACCGGCGAAACCATTACCAT
GGCGACCCGCCGGGCACTGGAGGAACGGCTGCGGCGCCTCGCAAACGTCGGAAATCGCGATGTCCTTCTCGAGGAGCTTG
CTGCCAGCCGTAAACGCTGGGCGAGGCTGCCTGTGCTCGACAACCGCTCTGTCGACGAGATTTTGGGGTATGACGAAAAC
GGGCTCCCCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L3LSG2

Antitoxin

Source ID Structure
AlphaFold DB A0A1L3L8D7

References