Detailed information of TA system TA057915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3358081..3358721
• Replicon: chromosome
• Accession: NZ_CP013106
• Organism: Halomonas huangheensis strain BJGMM-B45

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: AR456_RS14535
• Protein ID: WP_021818632.1
• Coordinates: 3358081..3358494 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: AR456_RS14540
• Protein ID: WP_031207572.1
• Coordinates: 3358491..3358721 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR456_RS14510	3353344..3354813	-	1470	WP_021818637.1	HAMP domain-containing histidine kinase	-
AR456_RS14515	3354825..3355520	-	696	WP_021818636.1	response regulator transcription factor	-
AR456_RS14520	3355835..3356179	+	345	WP_021818635.1	hypothetical protein	-
AR456_RS14525	3356312..3357193	+	882	WP_021818634.1	cytochrome b/b6 domain-containing protein	-
AR456_RS14530	3357186..3357974	+	789	WP_021818633.1	molybdopterin-binding protein	-
AR456_RS14535	3358081..3358494	-	414	WP_021818632.1	type II toxin-antitoxin system VapC family toxin	Toxin
AR456_RS14540	3358491..3358721	-	231	WP_031207572.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AR456_RS14545	3358979..3359335	-	357	WP_021818630.1	nucleotide pyrophosphohydrolase	-
AR456_RS14550	3359561..3360166	+	606	WP_021818629.1	sigma-70 family RNA polymerase sigma factor	-
AR456_RS14555	3360163..3360912	+	750	WP_021818628.1	anti-sigma factor	-
AR456_RS14560	3361035..3361466	+	432	WP_021818627.1	hypothetical protein	-
AR456_RS14565	3362313..3363596	+	1284	WP_031207570.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-127)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15204.54 Da
• Isoelectric Point: 6.2195

>T57915 WP_021818632.1 NZ_CP013106:c3358494-3358081 [Halomonas huangheensis]
MTCYMLDTCICSFIMREHPIAVIQRLADEAEQGSRIVVSAITYAEMRYGQIGKKASTKHKVLVDEFVRRLDAVLAWDQRA
VDATVEVMRELRIAGTPIGPNDTAIAGHAISAGCTLVTNNVREFGRVPSLVYEDWCS

Nucleotide

• Length: 414 bp

>T57915 NZ_CP013106:c3358494-3358081 [Halomonas huangheensis]
ATGACCTGCTATATGCTCGATACCTGTATTTGTTCCTTCATCATGCGGGAGCATCCTATTGCGGTGATTCAGCGGTTGGC
TGATGAGGCTGAGCAGGGCAGCCGGATTGTTGTCTCGGCCATTACTTATGCCGAGATGCGTTACGGCCAGATAGGCAAAA
AGGCCTCTACCAAGCACAAGGTACTAGTGGACGAGTTTGTGAGACGACTTGATGCTGTGCTGGCATGGGACCAGAGGGCG
GTGGACGCGACGGTAGAGGTCATGCGCGAGCTACGTATTGCTGGCACTCCCATTGGGCCCAATGATACGGCGATAGCGGG
TCATGCAATCTCTGCTGGTTGTACGCTGGTAACCAATAACGTGCGTGAATTTGGTCGCGTTCCGAGCCTTGTATACGAAG
ACTGGTGCTCTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8506.61 Da
• Isoelectric Point: 4.5702

>AT57915 WP_031207572.1 NZ_CP013106:c3358721-3358491 [Halomonas huangheensis]
MRTVSIFKNGKNQAVRLPADMAYEGVGELEISREGDVITLRPARPSWLSLPEFSKADADFLEERPVVVSDEGRFNP

Nucleotide

• Length: 231 bp

>AT57915 NZ_CP013106:c3358721-3358491 [Halomonas huangheensis]
ATGCGTACTGTATCCATTTTCAAGAATGGCAAGAACCAGGCTGTCCGTCTGCCAGCAGATATGGCCTATGAAGGCGTTGG
GGAGCTGGAAATTTCGCGAGAAGGCGATGTCATCACTCTTCGGCCTGCCCGGCCTTCCTGGCTATCTCTTCCTGAGTTCT
CGAAAGCTGATGCTGACTTCCTGGAAGAGCGACCTGTTGTTGTCAGTGATGAAGGCAGGTTCAATCCATGA