Detailed information of TA system TA057914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2265119..2265666
• Replicon: chromosome
• Accession: NZ_CP013106
• Organism: Halomonas huangheensis strain BJGMM-B45

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W1ND27
• Locus tag: AR456_RS10020
• Protein ID: WP_021817542.1
• Coordinates: 2265119..2265394 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AR456_RS10025
• Protein ID: WP_021817541.1
• Coordinates: 2265394..2265666 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR456_RS09995	2260236..2261870	+	1635	WP_021817547.1	dihydroxyacetone kinase subunit DhaK	-
AR456_RS10000	2261886..2262458	-	573	WP_021817546.1	GrpB family protein	-
AR456_RS10005	2262630..2263526	-	897	WP_021817545.1	class A beta-lactamase	-
AR456_RS10010	2263829..2264644	-	816	WP_021817544.1	aminotransferase class IV family protein	-
AR456_RS10015	2264737..2265090	+	354	WP_021817543.1	MerR family transcriptional regulator	-
AR456_RS10020	2265119..2265394	-	276	WP_021817542.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AR456_RS10025	2265394..2265666	-	273	WP_021817541.1	ribbon-helix-helix domain-containing protein	Antitoxin
AR456_RS10030	2266037..2266462	-	426	WP_021817540.1	YeeE/YedE family protein	-
AR456_RS10035	2266472..2266903	-	432	WP_021817539.1	YeeE/YedE family protein	-
AR456_RS10040	2266900..2267229	-	330	WP_021817538.1	metalloregulator ArsR/SmtB family transcription factor	-
AR456_RS10045	2267580..2268056	-	477	WP_081694581.1	cupin domain-containing protein	-
AR456_RS10050	2268076..2270274	-	2199	WP_051995692.1	thioredoxin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10645.29 Da
• Isoelectric Point: 9.5296

>T57914 WP_021817542.1 NZ_CP013106:c2265394-2265119 [Halomonas huangheensis]
MELKWTSKALSDLARLYEFLATVNQPAAARTVQQLTAAPTTLLTNPRIGELLEEFKPRDVRRILVGHYEMRYEITGSSIY
LLRLWHTREER

Nucleotide

• Length: 276 bp

>T57914 NZ_CP013106:c2265394-2265119 [Halomonas huangheensis]
ATGGAATTGAAGTGGACGAGTAAGGCCCTATCCGATTTGGCACGCCTCTACGAGTTCCTGGCGACAGTGAATCAGCCCGC
AGCAGCCCGTACGGTGCAACAGCTCACAGCGGCACCCACGACTCTGCTGACCAACCCGCGTATCGGCGAGCTGCTGGAAG
AATTCAAGCCGCGTGACGTGCGGCGGATTCTGGTCGGCCATTACGAGATGCGCTACGAGATCACGGGTTCTAGCATCTAT
CTGCTACGTCTGTGGCATACCCGTGAGGAGCGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10132.32 Da
• Isoelectric Point: 4.8433

>AT57914 WP_021817541.1 NZ_CP013106:c2265666-2265394 [Halomonas huangheensis]
MASTAKTRSVTAHVPIELAERVDEISNRLDRSKNWIVKQALAAWLDQEEERDRLTREALTDVDAGRVIDHQAVQAWADSL
STDTPLPVPR

Nucleotide

• Length: 273 bp

>AT57914 NZ_CP013106:c2265666-2265394 [Halomonas huangheensis]
ATGGCCTCCACTGCCAAGACTAGATCCGTTACCGCCCATGTCCCTATAGAGCTGGCTGAACGGGTCGATGAAATTTCCAA
CCGACTGGATCGCTCCAAAAACTGGATCGTCAAACAAGCCCTGGCCGCCTGGCTTGACCAGGAAGAGGAACGCGACCGCC
TGACCCGCGAGGCTCTGACCGATGTGGATGCCGGTCGTGTCATTGACCATCAGGCCGTGCAAGCCTGGGCCGACAGTCTG
AGTACCGATACTCCGCTGCCGGTACCACGCTGA

Structures

Toxin

• AlphaFold DB: W1ND27