Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1447694..1449444 Replicon chromosome
Accession NZ_CP013103
Organism Paraburkholderia caribensis strain MWAP64

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AN416_RS22600 Protein ID WP_054933313.1
Coordinates 1447694..1448587 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AN416_RS22605 Protein ID WP_054933339.1
Coordinates 1448584..1449444 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN416_RS22570 1443054..1444127 - 1074 WP_060604756.1 porin -
AN416_RS22575 1444569..1444886 + 318 WP_035998998.1 non-heme iron oxygenase ferredoxin subunit -
AN416_RS22580 1444888..1445199 + 312 WP_035999001.1 hypothetical protein -
AN416_RS22585 1445254..1446342 + 1089 WP_060604759.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AN416_RS22590 1446335..1447093 + 759 WP_054933312.1 SDR family oxidoreductase -
AN416_RS22595 1447129..1447668 + 540 WP_035999007.1 cupin domain-containing protein -
AN416_RS22600 1447694..1448587 + 894 WP_054933313.1 alpha/beta fold hydrolase Toxin
AN416_RS22605 1448584..1449444 + 861 WP_054933339.1 IclR family transcriptional regulator Antitoxin
AN416_RS22610 1449444..1450250 + 807 WP_060604762.1 SDR family oxidoreductase -
AN416_RS22615 1450243..1451901 + 1659 WP_060604765.1 thiamine pyrophosphate-binding protein -
AN416_RS22620 1451894..1452724 + 831 WP_054933316.1 aspartate dehydrogenase -
AN416_RS22625 1452749..1454245 + 1497 WP_060604768.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-276)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31101.10 Da        Isoelectric Point: 6.4894

>T57912 WP_054933313.1 NZ_CP013103:1447694-1448587 [Paraburkholderia caribensis]
MSAALPVTVDRTVTLETRLSHFPARRIAIAPQCAIGYREAGAGHADALPLVLLHGIGSGAASWVQQLDALGTTRRVFAWD
APGYGESTPVASASPKADEYAGALDAWLDALAVERCVLVGHSLGAIIAGSYAASRAQRVAGLLLISPAAGYGTASEDVRA
SKRDSRLAMLAELGPQGLADQRSANMLSPYADEASRDWVRWNMSRIVPTGYAQATHLLANADLASDVARVNGPIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAANEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T57912 NZ_CP013103:1447694-1448587 [Paraburkholderia caribensis]
ATGTCCGCAGCCTTGCCCGTCACTGTCGATCGAACCGTCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACGGCGGAT
CGCGATTGCGCCGCAATGCGCGATCGGCTATCGCGAAGCGGGTGCTGGGCACGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGTTCGGGCGCGGCTTCGTGGGTGCAACAACTCGACGCGTTGGGCACGACGCGCCGCGTGTTCGCTTGGGAC
GCGCCGGGCTATGGCGAATCGACGCCTGTTGCATCGGCTTCGCCCAAAGCAGATGAATATGCCGGCGCGCTCGACGCATG
GCTCGATGCGCTCGCCGTAGAACGTTGCGTACTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCTCGTACGCGGCAT
CGCGTGCGCAACGCGTCGCGGGGCTGTTGCTGATTTCGCCCGCGGCAGGCTACGGCACGGCATCCGAAGACGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGATGCTCGCCGAACTCGGCCCGCAAGGTCTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCCGTACGCCGATGAAGCATCACGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGACGGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGATCTCGCCAGCGATGTCGCGAGGGTCAACGGCCCAATCGCCGTCGCGGTCGGGGCG
GAGGACTCGATCACCCCGCCGTCGTCATGCGAGCGGATTGCACAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTACATCGAAGCGGCCAATGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGTCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31435.86 Da        Isoelectric Point: 6.5093

>AT57912 WP_054933339.1 NZ_CP013103:1448584-1449444 [Paraburkholderia caribensis]
MTPELTGTAPEAEDDRNDAGYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEALRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKTLERFTKHTPATVDELYERVRDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRGAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT57912 NZ_CP013103:1448584-1449444 [Paraburkholderia caribensis]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGGGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTCTCGCCGCGCGAACCGGTGCTCGGCGCGCCCGAATTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCACTGGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGTTCGCTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGCTTTGCGCGATGCAACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCATGCGCCCGTGTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGGCTACCCGCGCATGCGACTACGCAC
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTCGAACGCTTCACGAA
ACACACGCCCGCTACCGTTGACGAACTATACGAGCGCGTGAGGGACGACGCGGTGCGCGGTTTCGCGATCAGCGAATCGT
CCTTCGAAAACGGTATCTCCGTCATCAGTGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACCACCACC
ATTCCGCGCCCGCAGATCGACGCGGCGCTGCTCGACGGCGGCCTGATCGACAAGGTGCGCGGCGCGGCGGAGCAATTGTC
GCTGCGGCTGAACTACCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References