Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 2566801..2567461 Replicon chromosome
Accession NZ_CP013102
Organism Paraburkholderia caribensis strain MWAP64

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AN416_RS11335 Protein ID WP_082434037.1
Coordinates 2566801..2567229 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AN416_RS11340 Protein ID WP_060602697.1
Coordinates 2567216..2567461 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN416_RS11315 2562869..2563825 - 957 WP_054934558.1 sugar ABC transporter substrate-binding protein -
AN416_RS11320 2564376..2565014 + 639 WP_054934557.1 LysE family translocator -
AN416_RS11325 2565057..2566034 - 978 WP_054934556.1 magnesium/cobalt transporter CorA -
AN416_RS11330 2566239..2566712 - 474 WP_060601133.1 hypothetical protein -
AN416_RS11335 2566801..2567229 - 429 WP_082434037.1 type II toxin-antitoxin system VapC family toxin Toxin
AN416_RS11340 2567216..2567461 - 246 WP_060602697.1 hypothetical protein Antitoxin
AN416_RS11345 2567631..2568251 + 621 WP_060601137.1 ATP-binding protein -
AN416_RS11350 2568413..2569510 - 1098 WP_035990998.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
AN416_RS11355 2569718..2570182 - 465 WP_035990996.1 Lrp/AsnC family transcriptional regulator -
AN416_RS11360 2570319..2571203 - 885 WP_054934550.1 LysR family transcriptional regulator -
AN416_RS11365 2571356..2571868 + 513 WP_060601139.1 Spy/CpxP family protein refolding chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15715.91 Da        Isoelectric Point: 7.4682

>T57911 WP_082434037.1 NZ_CP013102:c2567229-2566801 [Paraburkholderia caribensis]
VYLIDTNVISEMRKSSRANPGVQAFFETAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFSSHI
LNVGTDVAQTWGHLRVPDPGHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Download         Length: 429 bp

>T57911 NZ_CP013102:c2567229-2566801 [Paraburkholderia caribensis]
GTGTATTTGATTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAATCCGGGCGTACAGGCTTTTTTCGA
AACGGCGAAGGAAGGCGGGCATCGCCTGTATCTGTCTGTGGTGACGGTTGGCGAGTTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCATTGCGCCTGGAAGGCTGGCTCGACACGATCATGAATTCGTTCAGCAGCCACATC
TTGAATGTCGGCACCGACGTTGCGCAGACGTGGGGCCATCTGCGCGTGCCCGACCCCGGGCATTCGCTGGACAAACTGAT
CGCGGCCACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TCAATCCGTTCCAGCTTCTCGACGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8910.88 Da        Isoelectric Point: 4.2208

>AT57911 WP_060602697.1 NZ_CP013102:c2567461-2567216 [Paraburkholderia caribensis]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPKKLSFAELLMSMPDVGDDADFERRNDATDDSGGPGVF
D

Download         Length: 246 bp

>AT57911 NZ_CP013102:c2567461-2567216 [Paraburkholderia caribensis]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTCTTTCAGCCCAAGAAGCTCAGCTTTGCGGAATTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGCAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References