Detailed information of TA system TA057910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 13405..13930
• Replicon: plasmid pCMCC50041
• Accession: NZ_CP013098
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CMCC50041

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: AC092_RS22655
• Protein ID: WP_001159863.1
• Coordinates: 13405..13710 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: AC092_RS22660
• Protein ID: WP_000813641.1
• Coordinates: 13712..13930 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC092_RS22615	8784..9344	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
AC092_RS25275	9500..9787	+	288	WP_071530243.1	hypothetical protein	-
AC092_RS22625	10064..10549	-	486	WP_000905606.1	membrane protein	-
AC092_RS22630	10543..11052	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
AC092_RS22635	11056..11769	-	714	WP_000545756.1	EAL domain-containing protein	-
AC092_RS22640	11778..12560	-	783	WP_000082169.1	site-specific integrase	-
AC092_RS22645	12595..13116	-	522	WP_000198608.1	hypothetical protein	-
AC092_RS22650	13113..13403	-	291	WP_001266176.1	hypothetical protein	-
AC092_RS22655	13405..13710	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
AC092_RS22660	13712..13930	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
AC092_RS22665	14606..15127	+	522	WP_077681952.1	hypothetical protein	-
AC092_RS25280	15171..15599	-	429	Protein_21	hypothetical protein	-
AC092_RS24870	15611..15906	+	296	Protein_22	cytoplasmic protein	-
AC092_RS22680	16400..17389	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
AC092_RS24375	17716..17877	-	162	WP_015059604.1	hypothetical protein	-
AC092_RS22685	17930..18316	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59373	59373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T57910 WP_001159863.1 NZ_CP013098:c13710-13405 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T57910 NZ_CP013098:c13710-13405 [Salmonella enterica subsp. enterica serovar Enteritidis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT57910 WP_000813641.1 NZ_CP013098:c13930-13712 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT57910 NZ_CP013098:c13930-13712 [Salmonella enterica subsp. enterica serovar Enteritidis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6