Detailed information of TA system TA057867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 2579663..2580194
• Replicon: chromosome
• Accession: NZ_CP013070
• Organism: Sphingobium indicum B90A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: T0GNF5
• Locus tag: SIDU_RS12470
• Protein ID: WP_004212690.1
• Coordinates: 2579663..2579944 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: T0G968
• Locus tag: SIDU_RS12475
• Protein ID: WP_004212689.1
• Coordinates: 2579931..2580194 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIDU_RS12445	2575715..2576188	+	474	WP_007683361.1	DUF305 domain-containing protein	-
SIDU_RS12450	2576247..2577782	+	1536	WP_007683359.1	PAS domain S-box protein	-
SIDU_RS12455	2577772..2578395	+	624	WP_007683357.1	response regulator transcription factor	-
SIDU_RS12460	2578477..2578884	+	408	WP_007683354.1	response regulator	-
SIDU_RS12465	2578947..2579297	-	351	WP_007683352.1	magnesium transporter	-
SIDU_RS12470	2579663..2579944	-	282	WP_004212690.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SIDU_RS12475	2579931..2580194	-	264	WP_004212689.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SIDU_RS12485	2580579..2581016	-	438	WP_007683347.1	metal-binding protein	-
SIDU_RS12490	2581096..2582337	-	1242	WP_007683345.1	MFS transporter	-
SIDU_RS12495	2582331..2583317	-	987	WP_009823975.1	copper resistance protein B	-
SIDU_RS12500	2583314..2585020	-	1707	WP_007683343.1	copper resistance system multicopper oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2530645..2589086	58441

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-76)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10993.49 Da
• Isoelectric Point: 7.4752

>T57867 WP_004212690.1 NZ_CP013070:c2579944-2579663 [Sphingobium indicum B90A]
MRTIERFGRFKRDYKREKKGQHAKTLDADLIPIIEALASDEPLEPRHRDHALTGDWRDHRDCHIKPDLVLIYRKPDDDTL
QLVRLGSHAELGW

Nucleotide

• Length: 282 bp

>T57867 NZ_CP013070:c2579944-2579663 [Sphingobium indicum B90A]
ATGCGGACGATTGAACGCTTCGGGCGGTTCAAGCGCGACTACAAGCGGGAGAAGAAGGGGCAGCACGCCAAGACGCTGGA
CGCTGACCTGATCCCGATCATCGAGGCGCTGGCATCCGACGAGCCGCTTGAACCGCGCCACCGCGACCATGCGCTGACCG
GCGACTGGCGCGACCATCGCGATTGCCACATAAAGCCCGACCTCGTGCTGATTTACCGCAAGCCCGATGACGACACCTTG
CAGCTTGTGCGCTTGGGATCGCACGCGGAATTGGGTTGGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9284.75 Da
• Isoelectric Point: 4.5881

>AT57867 WP_004212689.1 NZ_CP013070:c2580194-2579931 [Sphingobium indicum B90A]
MAANALVQTRIDGAVKEEAATVLAAMGLTVSDAVRLMLTRVARDKALPFEPLVPNAETIEAMKEAREGKGKRFATVVDLM
ADLNADD

Nucleotide

• Length: 264 bp

>AT57867 NZ_CP013070:c2580194-2579931 [Sphingobium indicum B90A]
ATGGCCGCAAACGCTCTTGTGCAGACCCGGATCGACGGAGCGGTGAAGGAGGAAGCCGCGACCGTGCTGGCTGCTATGGG
GCTGACCGTCTCCGATGCCGTGCGCCTGATGCTGACCCGCGTTGCCCGCGACAAGGCCTTGCCGTTTGAACCGCTGGTGC
CCAATGCCGAGACGATCGAGGCCATGAAGGAAGCGCGCGAGGGAAAGGGCAAGCGGTTCGCCACGGTGGTCGACCTGATG
GCCGACCTCAATGCGGACGATTGA

Structures

Toxin

• AlphaFold DB: T0GNF5

Antitoxin

• AlphaFold DB: T0G968