Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2405230..2405864 Replicon chromosome
Accession NZ_CP013070
Organism Sphingobium indicum B90A

Toxin (Protein)


Gene name vapC Uniprot ID T0GCG3
Locus tag SIDU_RS11765 Protein ID WP_007682494.1
Coordinates 2405230..2405619 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID T0GE84
Locus tag SIDU_RS11770 Protein ID WP_007682496.1
Coordinates 2405616..2405864 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SIDU_RS11730 2400544..2401096 + 553 Protein_2314 IS21 family transposase -
SIDU_RS11735 2401093..2401956 + 864 WP_004211466.1 IS21-like element helper ATPase IstB -
SIDU_RS11740 2402038..2402361 + 324 Protein_2316 transposase -
SIDU_RS11745 2402407..2403504 - 1098 WP_007683624.1 IS630 family transposase -
SIDU_RS11750 2403568..2404530 - 963 WP_007682488.1 tyrosine-type recombinase/integrase -
SIDU_RS11755 2404530..2404928 - 399 WP_007682491.1 hypothetical protein -
SIDU_RS11760 2404925..2405230 - 306 WP_007682492.1 hypothetical protein -
SIDU_RS11765 2405230..2405619 - 390 WP_007682494.1 type II toxin-antitoxin system VapC family toxin Toxin
SIDU_RS11770 2405616..2405864 - 249 WP_007682496.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SIDU_RS11775 2406033..2407436 - 1404 WP_013038665.1 efflux transporter outer membrane subunit -
SIDU_RS11780 2407429..2409159 - 1731 WP_073507145.1 efflux RND transporter permease subunit -
SIDU_RS11785 2409208..2410404 - 1197 WP_007684572.1 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14083.02 Da        Isoelectric Point: 4.5934

>T57866 WP_007682494.1 NZ_CP013070:c2405619-2405230 [Sphingobium indicum B90A]
MILDTSALVAILYREPEAATFAQAIHDADACRISVASYVELSMVIERQLGPEGMRQTEAFFRRAGITIEPVTLDHGELAR
QAFLDFGKGRHKAGLNFGDCFSYALAKATDEPLLFKGNDFALTDIEAAA

Download         Length: 390 bp

>T57866 NZ_CP013070:c2405619-2405230 [Sphingobium indicum B90A]
ATGATCCTCGACACCTCGGCCCTGGTCGCGATCCTCTATCGCGAACCCGAAGCGGCGACCTTCGCACAAGCCATCCATGA
TGCCGATGCCTGCCGCATCAGCGTCGCCAGCTATGTCGAGCTGTCGATGGTCATCGAACGCCAGCTCGGTCCCGAAGGGA
TGCGCCAGACCGAAGCCTTCTTTCGCCGCGCCGGCATCACGATCGAACCGGTGACGCTCGATCATGGCGAACTGGCGCGA
CAGGCGTTTCTCGATTTCGGCAAGGGCCGCCACAAAGCGGGCCTGAACTTTGGCGACTGCTTTTCCTATGCGCTGGCCAA
GGCGACCGACGAGCCGCTGTTGTTCAAGGGCAATGATTTTGCCCTGACGGACATAGAGGCGGCGGCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9203.47 Da        Isoelectric Point: 9.7320

>AT57866 WP_007682496.1 NZ_CP013070:c2405864-2405616 [Sphingobium indicum B90A]
MSLNVKDPEAHRLAQAIAQATGQSMTRVVTEALRERFARIERQKSKASVAELLTIADRAATHVKRPYVDHAELFYDDNGL
PK

Download         Length: 249 bp

>AT57866 NZ_CP013070:c2405864-2405616 [Sphingobium indicum B90A]
ATGAGCCTCAATGTTAAAGACCCTGAAGCCCATCGGCTTGCGCAGGCCATCGCCCAAGCGACCGGCCAGAGCATGACCCG
CGTGGTGACGGAGGCGCTGCGCGAGCGCTTCGCCAGGATCGAGCGTCAGAAAAGCAAGGCGAGCGTCGCGGAACTGCTAA
CGATCGCCGATCGCGCCGCCACGCATGTGAAGCGCCCCTATGTCGATCATGCCGAACTGTTTTATGACGATAATGGCCTG
CCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T0GCG3

Antitoxin

Source ID Structure
AlphaFold DB T0GE84

References