Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 617560..618227 Replicon chromosome
Accession NZ_CP013068
Organism Pannonibacter phragmitetus strain 31801

Toxin (Protein)


Gene name vapC Uniprot ID K2NQD8
Locus tag APZ00_RS02925 Protein ID WP_009452787.1
Coordinates 617560..617970 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K2NKX3
Locus tag APZ00_RS02930 Protein ID WP_009452788.1
Coordinates 617967..618227 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ00_RS02905 612936..613667 + 732 WP_009452783.1 hypothetical protein -
APZ00_RS02910 613876..614829 + 954 WP_157757082.1 hypothetical protein -
APZ00_RS02915 614876..615274 + 399 WP_143088047.1 hypothetical protein -
APZ00_RS02920 615271..617316 + 2046 WP_009452786.1 hypothetical protein -
APZ00_RS02925 617560..617970 - 411 WP_009452787.1 type II toxin-antitoxin system VapC family toxin Toxin
APZ00_RS02930 617967..618227 - 261 WP_009452788.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
APZ00_RS02935 618289..618714 - 426 WP_040673412.1 ribbon-helix-helix protein, CopG family -
APZ00_RS02940 618724..620724 - 2001 WP_009452790.1 conjugal transfer protein TraG -
APZ00_RS02945 620740..622518 - 1779 WP_058900529.1 VirD2 family relaxase/mobilization nuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15015.07 Da        Isoelectric Point: 5.2630

>T57861 WP_009452787.1 NZ_CP013068:c617970-617560 [Pannonibacter phragmitetus]
VSLRLLDTNAVISLVARRSDALLRRVEASEPGSLAVSSVVAHELYFGAYRSEKVAFNLETLRLLFADLGVLDFEREDARV
AGEIRAELKRQGTPIGPYDTLIAGQAKARNLTLVTNNTDEFSRIAGLQIEDWTIAR

Download         Length: 411 bp

>T57861 NZ_CP013068:c617970-617560 [Pannonibacter phragmitetus]
GTGAGCCTGCGTCTGCTCGACACCAATGCGGTGATCTCGCTGGTGGCGCGACGCTCCGATGCGTTGCTGCGACGAGTCGA
GGCGTCCGAACCTGGTTCACTGGCCGTTTCCTCCGTGGTCGCGCACGAACTCTATTTCGGTGCCTATCGCAGCGAGAAGG
TGGCGTTCAACCTCGAAACGCTCCGGCTCCTCTTTGCCGATCTCGGCGTCCTCGACTTTGAACGCGAAGACGCCCGCGTG
GCTGGCGAAATCCGGGCTGAGCTGAAGCGGCAGGGAACGCCGATCGGGCCATACGACACTCTCATCGCCGGGCAGGCCAA
GGCACGGAATCTCACGCTCGTCACTAACAATACCGATGAGTTTTCGCGTATCGCAGGGTTGCAGATCGAGGACTGGACCA
TAGCCAGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9860.85 Da        Isoelectric Point: 4.5610

>AT57861 WP_009452788.1 NZ_CP013068:c618227-617967 [Pannonibacter phragmitetus]
MPHIAKVFQSGNSQAVRLPKEFRFDVEEVEVSREGDAVILRPKSDTSRRWASLHAAVERGFSDDFMADGRDQPEDQERPE
LDQAFQ

Download         Length: 261 bp

>AT57861 NZ_CP013068:c618227-617967 [Pannonibacter phragmitetus]
ATGCCCCATATCGCTAAAGTCTTTCAGTCCGGCAACTCGCAGGCTGTCCGCTTGCCGAAGGAGTTTCGCTTCGATGTTGA
GGAGGTGGAGGTGTCGCGCGAAGGCGACGCTGTGATCCTGCGCCCGAAGTCCGACACAAGCCGTCGGTGGGCCTCGCTGC
ACGCCGCCGTCGAACGCGGCTTCAGCGACGACTTCATGGCCGACGGGCGCGACCAGCCCGAGGATCAGGAGCGTCCCGAA
CTCGATCAAGCGTTTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3PEV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3PG48

References