Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 520132..520721 Replicon chromosome
Accession NZ_CP013068
Organism Pannonibacter phragmitetus strain 31801

Toxin (Protein)


Gene name PumA Uniprot ID A0A0L0J3W5
Locus tag APZ00_RS02390 Protein ID WP_019963360.1
Coordinates 520428..520721 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0U3N8R6
Locus tag APZ00_RS02385 Protein ID WP_026355451.1
Coordinates 520132..520425 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ00_RS02365 516422..517474 - 1053 WP_058897968.1 FecR family protein -
APZ00_RS02370 517581..518090 - 510 WP_050472153.1 RNA polymerase sigma factor -
APZ00_RS02375 518350..519774 + 1425 WP_058897969.1 amino acid decarboxylase -
APZ00_RS02380 519783..520112 - 330 WP_019963358.1 type II toxin-antitoxin system HicB family antitoxin -
APZ00_RS02385 520132..520425 - 294 WP_026355451.1 putative addiction module antidote protein Antitoxin
APZ00_RS02390 520428..520721 - 294 WP_019963360.1 hypothetical protein Toxin
APZ00_RS02395 520799..521698 - 900 WP_019963361.1 LysR family transcriptional regulator -
APZ00_RS02400 521987..522784 + 798 WP_019963362.1 5-oxoprolinase subunit PxpA -
APZ00_RS02405 522781..523023 + 243 WP_058897970.1 biotin carboxyl carrier domain-containing protein -
APZ00_RS02410 523020..524402 + 1383 WP_058897971.1 acetyl-CoA carboxylase biotin carboxylase subunit -
APZ00_RS02415 524402..525277 + 876 WP_058897972.1 allophanate hydrolase subunit 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(7-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10935.79 Da        Isoelectric Point: 10.5155

>T57860 WP_019963360.1 NZ_CP013068:c520721-520428 [Pannonibacter phragmitetus]
MIEVRQTAVFRGWFAELKDLRARSRIARRIATVQSGLLGDVKFFDGIGELRIDYGPGYRVYFVRKGAVVIILLCGGDKGS
QARDIRKARMMAADLEE

Download         Length: 294 bp

>T57860 NZ_CP013068:c520721-520428 [Pannonibacter phragmitetus]
ATGATCGAAGTCCGCCAGACAGCCGTCTTTCGCGGCTGGTTTGCTGAGTTGAAAGACTTGCGCGCCCGAAGCCGGATCGC
CAGACGGATTGCTACCGTGCAAAGTGGTTTATTGGGCGATGTAAAATTCTTCGATGGCATAGGCGAGCTTCGTATCGATT
ATGGCCCGGGCTATCGCGTTTATTTCGTCCGCAAGGGTGCTGTGGTGATCATCCTGCTGTGCGGGGGAGACAAAGGCAGC
CAGGCCCGCGATATCCGTAAGGCCAGGATGATGGCTGCGGATCTGGAGGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10084.52 Da        Isoelectric Point: 4.3085

>AT57860 WP_026355451.1 NZ_CP013068:c520425-520132 [Pannonibacter phragmitetus]
MALETFPFDAAEHLTDPVDQAELLNEALGSGDAAAIASALGIIARARGMTEVAREAGVTRVALYKSLSEEGDPRLTTLLG
VMRALGMKLSAEITPAS

Download         Length: 294 bp

>AT57860 NZ_CP013068:c520425-520132 [Pannonibacter phragmitetus]
ATGGCACTTGAAACCTTTCCGTTCGATGCCGCCGAGCACCTGACAGATCCGGTTGATCAGGCCGAGTTGCTGAACGAAGC
CTTGGGAAGCGGAGATGCCGCCGCTATCGCTTCCGCCCTCGGGATCATTGCCCGGGCGCGCGGCATGACTGAAGTCGCCC
GCGAGGCCGGTGTAACCCGTGTCGCGCTTTACAAGTCTCTGAGTGAAGAGGGAGACCCCCGCCTGACAACCTTGCTGGGA
GTGATGCGGGCGCTTGGGATGAAGCTGTCTGCAGAGATTACGCCGGCTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0J3W5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3N8R6

References