Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 96954..97534 Replicon chromosome
Accession NZ_CP013068
Organism Pannonibacter phragmitetus strain 31801

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U3EI33
Locus tag APZ00_RS00415 Protein ID WP_058897738.1
Coordinates 96954..97337 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U3NA63
Locus tag APZ00_RS00420 Protein ID WP_058900488.1
Coordinates 97334..97534 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ00_RS00395 92023..93117 + 1095 WP_058897736.1 2'-deoxycytidine 5'-triphosphate deaminase -
APZ00_RS00400 93191..93838 - 648 WP_050470892.1 alpha/beta fold hydrolase -
APZ00_RS00405 93943..94701 - 759 WP_058897737.1 transporter substrate-binding domain-containing protein -
APZ00_RS00410 95088..96935 + 1848 WP_208991407.1 glycosyltransferase -
APZ00_RS00415 96954..97337 - 384 WP_058897738.1 type II toxin-antitoxin system VapC family toxin Toxin
APZ00_RS00420 97334..97534 - 201 WP_058900488.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
APZ00_RS00430 98072..98866 + 795 WP_058897739.1 ion transporter -
APZ00_RS00435 99035..100132 - 1098 WP_058897740.1 quinone-dependent dihydroorotate dehydrogenase -
APZ00_RS00440 100143..100487 - 345 WP_058897741.1 DUF952 domain-containing protein -
APZ00_RS00445 100694..101344 + 651 WP_058897742.1 helix-turn-helix transcriptional regulator -
APZ00_RS26205 101401..101676 - 276 WP_157757065.1 hypothetical protein -
APZ00_RS26210 101824..102216 + 393 WP_157757066.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14316.46 Da        Isoelectric Point: 6.7693

>T57858 WP_058897738.1 NZ_CP013068:c97337-96954 [Pannonibacter phragmitetus]
MILADTSIWIDHFRSFDPELQLVIENDSLLCHPAIIGELALGSLRDRREVLSFLTAQRSVTIASHEEVMGMIERHHLFNI
GIGYTDAHLLASTLIDSRAHLWTRDKRLRAAAEKAGARLYPHVLAAH

Download         Length: 384 bp

>T57858 NZ_CP013068:c97337-96954 [Pannonibacter phragmitetus]
ATGATTCTGGCTGACACATCAATCTGGATCGATCATTTCCGAAGCTTCGATCCGGAGCTTCAGCTGGTCATCGAGAATGA
CAGCTTGCTGTGCCATCCTGCCATCATCGGTGAACTTGCTCTTGGAAGTTTGCGAGACAGGAGGGAAGTACTCTCTTTTC
TGACTGCGCAACGTAGTGTCACCATTGCCTCACATGAGGAGGTCATGGGCATGATCGAGCGGCATCACCTCTTCAACATT
GGGATTGGATATACCGATGCCCATTTGCTGGCATCTACGCTCATAGACAGCCGTGCGCACCTTTGGACGCGGGATAAAAG
GCTGCGTGCTGCGGCTGAGAAGGCCGGAGCGAGACTGTACCCGCACGTTCTTGCTGCGCACTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7120.14 Da        Isoelectric Point: 10.6826

>AT57858 WP_058900488.1 NZ_CP013068:c97534-97334 [Pannonibacter phragmitetus]
MRSTINIDDALLEKARNLTGTKETAAIVRQALETLVRIETGRRLIALGGSMPDAEAAPRRRSASGE

Download         Length: 201 bp

>AT57858 NZ_CP013068:c97534-97334 [Pannonibacter phragmitetus]
ATGCGGTCAACTATCAATATTGACGATGCTTTGCTTGAGAAGGCCCGTAACCTGACCGGCACAAAGGAAACGGCTGCGAT
AGTGCGGCAGGCACTGGAGACGCTGGTACGCATCGAGACAGGTAGGCGCCTCATAGCGCTTGGTGGCTCCATGCCCGATG
CAGAGGCTGCTCCGCGCCGCAGGAGTGCATCCGGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3EI33

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3NA63

References