Detailed information of TA system TA057849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 1586197..1587133
• Replicon: plasmid C
• Accession: NZ_CP013054
• Organism: Sinorhizobium americanum CCGM7

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SAMCCGM7_RS28985
• Protein ID: WP_083541733.1
• Coordinates: 1586197..1586688 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A1L3LF60
• Locus tag: SAMCCGM7_RS28990
• Protein ID: WP_037384278.1
• Coordinates: 1586762..1587133 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMCCGM7_RS28965	1581841..1582698	+	858	WP_037384286.1	sulfate ABC transporter permease subunit CysT	-
SAMCCGM7_RS28970	1582688..1583572	+	885	WP_037384285.1	sulfate ABC transporter permease subunit CysW	-
SAMCCGM7_RS28975	1583588..1584697	+	1110	WP_037384284.1	sulfate/molybdate ABC transporter ATP-binding protein	-
SAMCCGM7_RS28980	1584836..1586200	+	1365	WP_037384282.1	FAD-binding oxidoreductase	-
SAMCCGM7_RS28985	1586197..1586688	-	492	WP_083541733.1	RES family NAD+ phosphorylase	Toxin
SAMCCGM7_RS28990	1586762..1587133	-	372	WP_037384278.1	DUF2384 domain-containing protein	Antitoxin
SAMCCGM7_RS28995	1587219..1588004	-	786	WP_037384276.1	crotonase/enoyl-CoA hydratase family protein	-
SAMCCGM7_RS29000	1588001..1588870	-	870	WP_037384275.1	hydroxymethylglutaryl-CoA lyase	-
SAMCCGM7_RS29005	1588867..1590855	-	1989	WP_037384273.1	acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha	-
SAMCCGM7_RS29010	1590872..1591255	-	384	WP_037384269.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	katA / htpB	1..2249899	2249899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-156)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18210.59 Da
• Isoelectric Point: 6.4818

>T57849 WP_083541733.1 NZ_CP013054:c1586688-1586197 [Sinorhizobium americanum CCGM7]
MTLWRAFVPRWAHMPLSGEGAARFGGRWNPVGTPTIYAARELSTAWAEYNQGFVQHPALIVQLELRQAKLADLTDSDVLA
ERGLEEALHRCEWRDELDRGSVPQTHKAQAGLLKDGYDGVIYPSYMSPGGTCVALWRWNGRSGPRLDVIDPEGRLPQSPA
SWL

Nucleotide

• Length: 492 bp

>T57849 NZ_CP013054:c1586688-1586197 [Sinorhizobium americanum CCGM7]
ATGACGCTCTGGCGTGCCTTCGTGCCACGCTGGGCCCATATGCCGCTTTCCGGCGAGGGCGCCGCCCGCTTCGGCGGCCG
ATGGAACCCCGTCGGAACGCCAACGATCTACGCGGCGCGGGAGCTTTCGACCGCCTGGGCCGAATATAACCAGGGCTTCG
TGCAGCACCCGGCGCTGATCGTGCAACTTGAGCTTCGCCAGGCGAAGCTGGCGGACCTGACGGACAGCGATGTGCTTGCC
GAACGCGGGCTCGAAGAGGCGCTTCACCGCTGCGAGTGGCGCGACGAACTCGACAGGGGTTCGGTGCCGCAGACGCACAA
GGCCCAAGCCGGACTTTTGAAGGACGGCTACGACGGCGTGATCTACCCGTCCTACATGTCACCCGGCGGCACCTGTGTTG
CGCTCTGGCGCTGGAACGGCCGGAGCGGGCCGCGGCTCGACGTCATCGATCCGGAAGGCCGGCTGCCGCAATCGCCGGCC
TCGTGGCTTTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13143.29 Da
• Isoelectric Point: 9.7796

>AT57849 WP_037384278.1 NZ_CP013054:c1587133-1586762 [Sinorhizobium americanum CCGM7]
MMAVDFQIPAARFGDDHSPYLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAIRAGVYA

Nucleotide

• Length: 372 bp

>AT57849 NZ_CP013054:c1587133-1586762 [Sinorhizobium americanum CCGM7]
ATGATGGCTGTCGATTTCCAGATTCCGGCGGCTCGCTTCGGGGACGATCATTCGCCGTACCTGTCGGCGCGCCTCGTTGC
CGACCGGCTCGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGCGTCGCCCGCAACACGCTGACGGCAAAGTCCGGCG
CGCGAAAGGTCGACAGCGCTTTGAGCAAGGTTGTTCGCATCCTCGCCATGGCGTCCGAAATGGCCGGCGACGAGGCCCGC
GCGGTCATCTGGTTCAAGCACCAGCCGATCCCCGGCTGGGCCGGCAAGACCGCCTATGATCTGGTCGGCGAAGGCAAGGC
CGACAAGGTCCTCGCTTATCTCGAGGCCATCCGCGCCGGCGTCTACGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1L3LF60